Analyze the similarity between mutational signatures from different analyses/runs. THis function can be helpful to match de novo extracted signatures with previously described signatures (such as COSMIC), or to reveal signatures that can be identified with alternative NMF algorithms, or that may be due to an algorithm bias.
matchSignatures(
mutSign,
reference = NULL,
method = "cosine",
threshold = 0.5,
plot = "TRUE"
)a mutationSignatures object
a mutationSignatures object. If NULL, COSMIC signatures will be retrieved
distance method used to compute similarity (1 - distance)
signal (similarity) upper threshold for maxing the signal
logical, shall a heatmap be plotted
list, including distance matrix and a heatmap plot
This function is part of the user-interface set of tools included in mutSignatures. This is an exported function.
More information and examples about mutational signature analysis can be found here:
GitHub Repo: https://github.com/dami82/mutSignatures/
More info and examples about the mutSignatures R library: https://www.data-pulse.com/dev_site/mutsignatures/
Sci Rep paper, introducing mutS: https://www.nature.com/articles/s41598-020-75062-0/
Oncogene paper, Mutational Signatures Operative in Bladder Cancer: https://www.nature.com/articles/s41388-017-0099-6