ncappc (version 0.1)

histobs.plot: Plots histogram of selected set of NCA metrics.

Description

histobs.plot plots histogram of selected set of NCA metrics (e.g. AUClast, AUCINF_obs, Cmax and Tmax).

Usage

histobs.plot(plotData, figlbl = NULL, param = c("AUClast", "AUCINF_obs",
  "Cmax", "Tmax"), cunit = "[M].[L]^-3", tunit = "[T]", spread = "pi")

Arguments

plotData

A data frame with the estimated NCA metrics

figlbl

Figure label based on dose identifier and/or population stratifier (NULL)

param

A character array of the NCA metrics. The allowed NCA metrics for this histograms are "AUClast", "AUClower_upper", "AUCINF_obs", "AUCINF_pred", "AUMClast", "Cmax", "Tmax" and "HL_Lambda_z". (c("AUClast","AUCINF_obs","Cmax","Tmax"))

cunit

Unit for concentration ("[M].[L]^-3")

tunit

Unit for time ("[T]")

spread

measure of the spread of simulated data (sd or pi (95% nonparametric prediction interval)) ("pi")

Value

• returns a graphical object created by arrangeGrob function

Details

histobs.plot plots histogram of selected set of NCA metrics. The allowed NCA metrics for this histograms are "AUClast", "AUClower_upper", "AUCINF_obs", "AUCINF_pred", "AUMClast", "Cmax", "Tmax" and "HL_Lambda_z". By default, this function produces histogram of AUClast, AUCINF_obs, Cmax and Tmax.