nca.npde.plot

nca.npde.plot plots individual NPDE values and histogram of the NPDE
values within a population group

A flexible tool that can perform
(i) traditional non-compartmental analysis (NCA) and
(ii) Simulation-based posterior predictive checks for population
pharmacokinetic (PK) and/or pharmacodynamic (PKPD) models using
NCA metrics. The methods are described in Acharya et al. (2016)
<doi:10.1016/j.cmpb.2016.01.013>.

Andrew C. Hooker

ncappc

NCA Calculations and Population Model Diagnosis

Chayan Acharya

Gulbeyaz Y. Turkyilmaz

Siv Jonsson

Mats O. Karlsson

nca.npde.plot function

<dl><dt>plotdata</dt>
<dd>Data frame with the values of the NPDE values of each
individual for the NCA metrics</dd>
<dt>xvar</dt>
<dd>Name of the independent variable column against which NPDE values
will be plotted</dd>
<dt>npdecol</dt>
<dd>Column names or column numbers of containing the NPDE values</dd>
<dt>figlbl</dt>
<dd>Figure label based on dose identifier and/or population
stratifier (NULL)</dd>
<dt>cunit</dt>
<dd>Unit for concentration (default is <code>NULL</code>)</dd>
<dt>tunit</dt>
<dd>Unit for time (default is <code>NULL</code>)</dd></dl>

Arguments

Plots population histogram of the NCA metrics selected for model diagnosis. — nca.npde.plot

<dl>

<dt>plotdata</dt>
<dd>Data frame with the values of the NPDE values of each
individual for the NCA metrics</dd>


<dt>xvar</dt>
<dd>Name of the independent variable column against which NPDE values
will be plotted</dd>


<dt>npdecol</dt>
<dd>Column names or column numbers of containing the NPDE values</dd>


<dt>figlbl</dt>
<dd>Figure label based on dose identifier and/or population
stratifier (NULL)</dd>


<dt>cunit</dt>
<dd>Unit for concentration (default is <code>NULL</code>)</dd>


<dt>tunit</dt>
<dd>Unit for time (default is <code>NULL</code>)</dd>

</dl>

nca.npde.plot: Plots population histogram of the NCA metrics selected for model diagnosis.

Description

Usage

Value

Arguments

Details