Noncompartmental Analysis of Pharmacokinetic Data for CDISC
Standardized Parameters
Description
Conduct a noncompartmental analysis as closely as possible to the most widely used commercial software for pharmacokinetic analysis, i.e. 'Phoenix(R) WinNonlin(R)' .
Some features include:
1) Use CDISC SDTM PP domain terms.
2) Automatic slope selection with the same criterion of WinNonlin(R)
3) Support both 'linear-up linear-down' and 'linear-up log-down' method
4) Calculate partial(interval) AUC with 'linear' or 'log' interpolation method
5) Perform a noncompartmental analysis of CDISC standardized pharmacokinetic dataset (.XPT)
For more details on noncompartmental analysis, see the reference: Gabrielsson J, Weiner D. Pharmacokinetic and Pharmacodynamic Data Analysis - Concepts and Applications. 5th ed. 2016. (ISBN:9198299107)
*) Acknowledgement: Author thanks for the careful review and valuable input of Dr. Jee Eun Lee.