runCDISC

Working directory of CDISC dataset, containing DM, EX and PC

A filename of DM domain. Usually DM or dm

filenameDM

A filename of EX domain. Usually EX or ex

filenameEX

A filename of PC domain. Usually PC or pc

filenamePC

file extension, currently supporting only <code>.xpt</code>

extension

incl_arm

<code>runCDISC</code> uses ncar package to perform a noncompartmental analysis of
CDISC standardized pharmacokinetic dataset.

Conduct a noncompartmental analysis as closely as possible to the most widely used commercial software for pharmacokinetic analysis, i.e. 'Phoenix(R) WinNonlin(R)' <https://www.certara.com/software/pkpd-modeling-and-simulation/phoenix-winnonlin/>.
Some features include:
1) Use CDISC SDTM PP domain terms and generate PP domains from DM, EX, and PC domains.
2) Automatic slope selection with the same criterion of WinNonlin(R)
3) Support both 'linear-up linear-down' and 'linear-up log-down' method
4) Calculate partial(interval) AUC with 'linear' or 'log' interpolation method
5) Perform a noncompartmental analysis of CDISC standardized pharmacokinetic dataset (.XPT)
For more details on noncompartmental analysis, see the reference: Gabrielsson J, Weiner D. Pharmacokinetic and Pharmacodynamic Data Analysis - Concepts and Applications. 5th ed. 2016. (ISBN:9198299107)
*) Acknowledgement: Author thanks for the careful review and valuable input of Dr. Jee Eun Lee.

runCDISC: Conduct a noncompartmental analysis with CDISC dataset

Description

Usage

Arguments

Value

Examples