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ncar (version 0.3.4)

Noncompartmental Analysis for Pharmacokinetic Data for Report

Description

Conduct a noncompartmental analysis as closely as possible to the most widely used commercial software for pharmacokinetic analysis, i.e. 'Phoenix(R) WinNonlin(R)' . Some features are 1) CDISC SDTM terms 2) Automatic slope selection with the same criterion of WinNonlin(R) 3) Supporting both 'linear-up linear-down' and 'linear-up log-down' method 4) Interval(partial) AUCs with 'linear' or 'log' interpolation method 5) Produce pdf, rtf, text report files. * Reference: Gabrielsson J, Weiner D. Pharmacokinetic and Pharmacodynamic Data Analysis - Concepts and Applications. 5th ed. 2016. (ISBN:9198299107).

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Version

Install

install.packages('ncar')

Monthly Downloads

384

Version

0.3.4

License

GPL-3

Maintainer

Kyun-Seop Bae

Last Published

March 17th, 2017

Functions in ncar (0.3.4)

ncar-package

Noncompartmental Analysis for Pharmacokinetic Data for Reviewer
LogAUC

Area Under the Curve(AUC) and Area Under the first Moment Curve(AUMC) by linear-up log-down method
Unit

Disply CDISC standard units and multiplied factor of NCA results
Round

Round Half Away from Zero
sNCA

Simplest NCA
tabNCA

Table output NCA
AUC

Calculate Area Under the Curve (AUC) and Area Under the first Moment Curve (AUMC) in a table format
BasicUtil

Internal Functions
txtNCA

Text output of NCA
BestSlope

Choose best fit slope for the log(y) and x regression by the criteria of adjusted R-square
IntAUC

Calculate interval AUC
RptCfg

NCA Report Configuation Table
Slope

Get the Slope of regression log(y) ~ x
LinAUC

Area Under the Curve(AUC) and Area Under the first Moment Curve(AUMC) by linear trapezoidal method
Interpol

Interpolate y value
pdfNCA

NCA output to pdf file
rtfNCA

NCA output to rtf file