R package netmeta provides frequentist methods for network meta-analysis and supports Schwarzer et al. (2015), Chapter 8 on network meta-analysis http://meta-analysis-with-r.org/.
R package netmeta is an add-on package for meta providing the following meta-analysis methods:
frequentist network meta-analysis (function
netmeta) based on R<U+00FC>cker (2012) and R<U+00FC>cker &
Schwarzer (2014);
net heat plot (netheat) and design-based
decomposition of Cochran's Q (decomp.design)
described in Krahn et al. (2013);
measures characterizing the flow of evidence between two
treatments (netmeasures) described in K<U+00F6>nig et
al. (2013);
ranking of treatments (netrank) based on
frequentist analogue of SUCRA (R<U+00FC>cker & Schwarzer, 2015);
partial order of treatment rankings (netposet,
plot.netposet) and Hasse diagram
(hasse) according to Carlsen & Bruggemann (2014)
and R<U+00FC>cker & Schwarzer (2017);
split direct and indirect evidence (netsplit)
to check for consistency (Dias et al., 2010; Efthimiou et al.,
2019);
league table with network meta-analysis results
(netleague);
additive network meta-analysis for combinations of treatments
(netcomb, discomb for disconnected
networks) (R<U+00FC>cker et al., 2019);
network meta-analysis of binary data
(netmetabin) using the Mantel-Haenszel or
non-central hypergeometric distribution method (Efthimiou et al.,
2019);
‘comparison-adjusted’ funnel plot
(funnel.netmeta) to assess funnel plot asymmetry in
network meta-analysis (Chaimani & Salanti, 2012)
automated drawing of network graphs
(netgraph.netmeta) described in R<U+00FC>cker & Schwarzer
(2016);
results of several network meta-analyses can be combined with
netbind to show these results in a forest plot.
Furthermore, functions and datasets from netmeta are utilised in Schwarzer et al. (2015), Chapter 8 "Network Meta-Analysis", http://meta-analysis-with-r.org/.
Type help(package = "netmeta") for a listing of all R
functions available in netmeta.
Type citation("netmeta") on how to cite netmeta in
publications.
To report problems and bugs
type bug.report(package = "netmeta") if you do not use
RStudio,
send an email to Guido Schwarzer sc@imbi.uni-freiburg.de if you use RStudio.
The development version of netmeta is available on GitHub https://github.com/guido-s/netmeta.
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Chaimani A & Salanti G (2012): Using network meta-analysis to evaluate the existence of small-study effects in a network of interventions. Research Synthesis Methods, 3, 161--76
Dias S, Welton NJ, Caldwell DM, Ades AE (2010): Checking consistency in mixed treatment comparison meta-analysis. Statistics in Medicine, 29, 932--44
Efthimiou O, R<U+00FC>cker G, Schwarzer G, Higgins J, Egger M, Salanti G (2019): A Mantel-Haenszel model for network meta-analysis of rare events. Statistics in Medicine, 1--21, https://doi.org/10.1002/sim.8158
K<U+00F6>nig J, Krahn U, Binder H (2013): Visualizing the flow of evidence in network meta-analysis and characterizing mixed treatment comparisons. Statistics in Medicine, 32, 5414--29
Krahn U, Binder H, K<U+00F6>nig J (2013): A graphical tool for locating inconsistency in network meta-analyses. BMC Medical Research Methodology, 13, 35
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R<U+00FC>cker G, Schwarzer G (2014): Reduce dimension or reduce weights? Comparing two approaches to multi-arm studies in network meta-analysis. Statistics in Medicine, 33, 4353--69
R<U+00FC>cker G, Schwarzer G (2015): Ranking treatments in frequentist network meta-analysis works without resampling methods. BMC Medical Research Methodology, 15, 58
R<U+00FC>cker G, Schwarzer G (2016): Automated drawing of network plots in network meta-analysis. Research Synthesis Methods, 7, 94--107
R<U+00FC>cker G, Schwarzer G (2017): Resolve conflicting rankings of outcomes in network meta-analysis: Partial ordering of treatments. Research Synthesis Methods, 8, 526--36
R<U+00FC>cker G, Petropoulou M, Schwarzer G (2019): Network meta-analysis of multicomponent interventions. Biometrical Journal, 1--14, https://doi.org/10.1002/bimj.201800167
Schwarzer G, Carpenter JR and R<U+00FC>cker G (2015): Meta-Analysis with R (Use-R!). Springer International Publishing, Switzerland.