nlmeODE (version 0.2-7)

TheophODE: Pharmacokinetics of theophylline

Description

The Theoph data frame has 132 rows and 6 columns of data from an experiment on the pharmacokinetics of theophylline.

source

Boeckmann, A. J., Sheiner, L. B. and Beal, S. L. (1994), NONMEM Users Guide: Part V, NONMEM Project Group, University of California, San Francisco. Davidian, M. and Giltinan, D. M. (1995) Nonlinear Models for Repeated Measurement Data, Chapman & Hall (section 5.5, p. 145 and section 6.6, p. 176) Pinheiro, J. C. and Bates, D. M. (2000) Mixed-effects Models in S and S-PLUS, Springer (Appendix A.29)

Details

Boeckmann, Sheiner and Beal (1994) report data from a study by Dr. Robert Upton of the kinetics of the anti-asthmatic drug theophylline. Twelve subjects were given oral doses of theophylline then serum concentrations were measured at 11 time points over the next 25 hours. These data are analyzed in Davidian and Giltinan (1995) and Pinheiro and Bates (2000) using a two-compartment open pharmacokinetic model, for which a self-starting model function, SSfol, is available.

See Also

Theoph, SSfol

Examples

data(Theoph)

TheophODE <- Theoph
TheophODE$Dose[TheophODE$Time!=0] <- 0
TheophODE$Cmt <- rep(1,dim(TheophODE)[1])

OneComp <- list(DiffEq=list(               
                    dy1dt = ~ -ka*y1 ,     
                    dy2dt = ~ ka*y1-ke*y2),
                ObsEq=list(                
                    c1 = ~ 0,
                    c2 = ~ y2/CL*ke),
                Parms=c("ka","ke","CL"),   
                States=c("y1","y2"),       
                Init=list(0,0))
                
TheophModel <- nlmeODE(OneComp,TheophODE)

#Remove '#' below to run the estimation

#Theoph.nlme <- nlme(conc ~ TheophModel(ka,ke,CL,Time,Subject),
#   data = TheophODE, fixed=ka+ke+CL~1, random = pdDiag(ka+CL~1), 
#   start=c(ka=0.5,ke=-2.5,CL=-3.2),
#   control=list(returnObject=TRUE,msVerbose=TRUE,tolerance=1e-1,pnlsTol=1e-1,msTol=1e-1),
#   verbose=TRUE)

#plot(augPred(Theoph.nlme,level=0:1))