Calculate gnlmm variance-covariance matrix of fixed effects
Generate an SAEM model
Forward covariate selection for nlme-base non-linear mixed effect models
Sets nodes and weigts of Gauss-Hermite quadrature
Messages the nlmixr logo...
Parameters for a linear compartment model for SAEM
concentrations from a linear compartment model
Extract log likelihood for focei fit
Fit a non-population dynamic model using mcmc
Predict a nlmixr solved system
Prepares the UI function and returns a list.
Fit a non-population dynamic model
Inverse Guassian absorption model
Convert/Format the data appropriately for nlmixr
Fit a generalized nonlinear mixed-effect model
Extract the fitted values from the model
Construct RxODE linCmt function
Get ETA names
Get the FOCEi theta or eta specification for model.
instant.stan.extension.
Parent/Metabolite dataset
Get the FOCEi initilizations
Create the nlme specs list for nlmixr nlme solving
Nelder-Mead of simplex search
Calculate gnlmm variance-covariance matrix of random effects
Augmented Prediction for nlmixr fit
Clear memoise cache for nlmixr
Access the model list information for nlmixr's nlme user functions
FOCEI Fit for nlmixr
nlmixrBounds.focei.upper.lower
Get upper/lower/names for THETAs
Get the FOCEi theta specification for the model
Get saem initilization list
Get a list of directories for inclusion
Print x using the message facility
Get the variance for the nlme fit process based on UI
Pregnant Rat Diet Experiment
SAEM's init$omega
GOF plots for nlme-based mixed-effect models
Simulate a nlmixr solved system
Objects exported from other packages
Get the SAEM model$res.mod code
Fit nlme-based linear compartment mixed-effect model using closed form solution
Create the nlme parameter transform function from the UI object.
Print an SAEM model fit summary
Summary of a non-population dynamic model fit using mcmc
Build linear solved information based on defined parameters.
Return RxODE model with predictions appended
Plot a focei.fit plot
Validate nlmixr
Extract the Nlmixr bound information from a function.
Generate SAEM initial estimates for THETA.
Fit nlme-based mixed-effect model using ODE implementation
Get model$log.eta for SAEM
Dispaly nlmixr's version
nlmixr fits population PK and PKPD non-linear mixed effects models.
Get initial estimate for ares SAEM.
Plot an SAEM model fit
Get the eta->eta.trans for SAEM
Generate saem.fit user function.
Get initial estimate for bres SAEM.
Extract residuals from the FOCEI fit
Get error names for SAEM
Control Options for SAEM
FOCEI ETA setup,
Generate SAEM model list
VPC for nlmixr saemFit objects
Summary of a non-population dynamic model fit
Visual predictive check (VPC) for nlmixr nlme objects
Fit a nlmixr model
nlmixrUI.saem.model.omega
Get the SAEM model Omega
Get THETA names for nlmixr's SAEM
Extract the number of observations for the focei fit
Parameter history extraction
Plot of a non-population dynamic model fit
Get the Parameter function with THETA/ETAs defined
Calculate the Gradient for an individual
Find the assignments in R expression
Convert NONMEM/Monolix data to RxODE/nlmixr style data
Prediction after a gnlmm fit
Plot of a non-population dynamic model fit using mcmc
Summary of a non-population dynamic model fit using mcmc
Print a focei fit
Solve the FOCEI inner problem
Print an SAEM model fit summary
Print a non-population dynamic model fit object
Print a gnlmm fit
Print UI function
Get -LLIK for individual
Pump failure example dataset
Get -Grad for individual
Cleanup saem_fit environment by removing dll after the object is no logner used by R.
Fit an SAEM model
Get the Hessian for the environment
Produce trace-plot for fit if applicable
Update ETAs based on d(eta)/d(theta)
Multiple dose Theophiline PK data
Extract variance/covariance matrix for FOCEI fit
FOCEI THETA setup,
Returns the gradient for FOCEi environment
VPC based on ui model
Multiple dose Theophiline PK data
Convert fit to FOCEi style fit
2 Compartment Model with Michelis Menton Clearance
Get the Function pointers for the LBJ'S routine
RxODE_focei_finalize_llik
Finalize likelihood environment
Configure an SAEM model
Get the likelihood for ETA
Bootstrap data
2 Compartment Model
Simulated Data Set for comparing objective functions
Oral_1CPT -- 1 Compartment Model with Oral Absorption Simulated Data from ACOP 2016
Get the likelihood slope for ETA
Infusion_1CPT -- 1 Compartment Model Simulated Data from ACOP 2016
Bolus_1CPT -- 1 Compartment Model Simulated Data from ACOP 2016
1 Compartment Model w/ Michelis Menton Elimination
Return composite saem/focei to saem
Collect warnings and just warn once.
Convert focei fit to a data.frame
Return composite nlme/focei to nlme