Wang2007

This is a simulated dataset from Wang2007 where various NONMEM
estimation methods (Lapclace FO, FOCE with and without
interaction) are described.

datasets

Fit and compare nonlinear mixed-effects models in differential
equations with flexible dosing information commonly seen in pharmacokinetics
and pharmacodynamics (Almquist, Leander, and Jirstrand 2015
<doi:10.1007/s10928-015-9409-1>). Differential equation solving is
by compiled C code provided in the 'RxODE' package
(Wang, Hallow, and James 2015 <doi:10.1002/psp4.12052>).

Wenping Wang

nlmixr

Nonlinear Mixed Effects Models in Population Pharmacokinetics
and Pharmacodynamics

Matthew Fidler

Yuan Xiong

Rik Schoemaker

Justin Wilkins

Mirjam Trame

Teun Post

Robert Leary

Hadley Wickham

Dirk Eddelbuettel

David Ardia

Katharine Mullen

Wang2007 function

A data frame with 20 rows and 3 columns<dl class="dl-horizontal">
 <dt>ID</dt><dd>Siumlated Subject ID</dd>
 <dt>Time</dt><dd>Simulated Time</dd>
 <dt>Y</dt><dd>Simulated Objective Function</dd>
</dl>

Format

Simulated Data Set for comparing objective functions — Wang2007

A data frame with 20 rows and 3 columns<dl class='dl-horizontal'>
 <dt>ID</dt><dd>Siumlated Subject ID</dd>
 <dt>Time</dt><dd>Simulated Time</dd>
 <dt>Y</dt><dd>Simulated Objective Function</dd>
</dl>

Simulated Data Set for comparing objective functions

Wang2007: Simulated Data Set for comparing objective functions

Description

Usage

Arguments

Format