Simulated Data Set for comparing objective functions
NPDE calculation for nlmixr
2 Compartment Model with Michelis Menton Clearance
Bolus_1CPT -- 1 Compartment Model Simulated Data from ACOP 2016
Add CWRES
Return VarCorr for nlmixr nlme
1 Compartment Model w/ Michelis Menton Elimination
2 Compartment Model
Infusion_1CPT -- 1 Compartment Model Simulated Data from ACOP 2016
Calculate gnlmm variance-covariance matrix of fixed effects
Return composite saem/focei to saem
Log-likelihood using Gaussian Quadrature
Covariance matrix by Fisher Information Matrix via linearization
Oral_1CPT -- 1 Compartment Model with Oral Absorption Simulated Data from ACOP 2016
Get the FOCEi theta specification for the model
Get the FOCEi theta or eta specification for model.
Fit a non-population dynamic model
Fit a non-population dynamic model using mcmc
Generalized Cholesky Matrix Decomposition
This gets the parsed data in the lower-level manner that nlmixr expects.
Control Options for FOCEi
Convert fit to FOCEi style fit
Return composite nlme/focei to nlme
Forward covariate selection for nlme-base non-linear mixed effect models
Change a nlmixr fit object to a huxtable
Bootstrap data
Cox Box, Yeo Johnson and inverse transformation
FOCEi fit
concentrations from a linear compartment model
nlmixr model block
nlmixrBounds.focei.upper.lower
Get upper/lower/names for THETAs
Get parameters that are fixed
Clear memoise cache for nlmixr
Parent/Metabolite dataset
Convert/Format the data appropriately for nlmixr
instant.stan.extension.
Get the FOCEi initializations
Inverse Guassian absorption model
Generate saem.fit user function.
Sets nodes and weigts of Gauss-Hermite quadrature
Calculate gnlmm variance-covariance matrix of random effects
Get ETA names
Construct RxODE linCmt function
Generate an SAEM model
Extract the Nlmixr bound information from a function.
Get initial estimate for ares SAEM.
Configure an SAEM model
Get parameters that are fixed for SAEM
Get initial estimate for bres SAEM.
Fit nlme-based linear compartment mixed-effect model using closed form solution
Fit/Evaulate FOCEi
Create a run summary word document
Convert data to RxODE format (depreciated)
Extract residuals from the FOCEI fit
Access the model list information for nlmixr's nlme user functions
GOF plots for nlme-based mixed-effect models
Parameters for a linear compartment model for SAEM
Calculate Hessian
Create a gradient function based on gill numerical differences
Create the nlme parameter transform function from the UI object.
Fit a generalized nonlinear mixed-effect model
Get the optimal forward difference interval by Gill83 method
Generate SAEM model list
Cleanup saem_fit environment by removing dll after the object is no logner used by R.
nlmixrUI.saem.distribution
Get SAEM distribution
Get the eta->eta.trans for SAEM
Get the SAEM model$res.mod code
nlmixrUI.saem.model.omega
Get the SAEM model Omega
Get the Parameter function with THETA/ETAs defined
Get THETA names for nlmixr's SAEM
Create a large output based on a nlmixr fit
nlmixr fits population PK and PKPD non-linear mixed effects models.
nlmixr ini block handling
Fit an SAEM model
Return RxODE model with predictions appended
Augmented Prediction for nlmixr fit
Get error names for SAEM
Nelder-Mead of simplex search
Print a non-population dynamic model fit object
Control Options for SAEM
Print x using the message facility
Simulate a nlmixr solved system
Return dynmodel variable translation function
Prepares the UI function and returns a list.
Fit a nlmixr model
Find the assignments in R expression
Get saem initilization list
SAEM's init$omega
Prediction after a gnlmm fit
Plot an SAEM model fit
VPC for nlmixr saemFit objects
Visual predictive check (VPC) for nlmixr nlme objects
Pump failure example dataset
Print an SAEM model fit summary
Single Dose Phenobarbitol PK/PD
Plot of a non-population dynamic model fit using mcmc
Plot of a non-population dynamic model fit
Print a gnlmm fit
Print UI function
Plot a nlmixr data object
Create the nlme specs list for nlmixr nlme solving
Messages the nlmixr logo...
Fit nlme-based mixed-effect model using ODE implementation
Predict a nlmixr solved system
Get the variance for the nlme fit process based on UI
Generate SAEM initial estimates for THETA.
Print an SAEM model fit summary
Output table/data.frame options
Set Objective function type for a nlmixr object
Return the square root of general square matrix A
Validate nlmixr
Get model$log.eta for SAEM
Multiple dose Theophiline PK data
Summary of a non-population dynamic model fit using mcmc
Warfarin PK/PD data
VPC based on ui model
Multiple dose Theophiline PK data
Dispaly nlmixr's version
Get a list of directories for inclusion
Pregnant Rat Diet Experiment
Return the objective function
Objects exported from other packages
Summary of a non-population dynamic model fit using mcmc
Produce trace-plot for fit if applicable
Summary of a non-population dynamic model fit
Vpc function for nlmixr