nlmixr (version 1.1.1-2)

pheno_sd: Single Dose Phenobarbitol PK/PD

Description

This is from a PK study in neonatal infants. They received multiple doses of phenobarbital for seizure prevention.

Usage

pheno_sd

Arguments

Format

A data frame with 744 rows and 8 columns

ID

Infant ID

TIME

Time of (hr)

AMT

Dose in (ug/kg)

WT

Weight in kg

APGR

A 5-minute Apgar score to measure infant health

DV

The concentration of phenobarbitol in the serum (ug/mL)

MDV

If the dependent variable (DV) is missing; 0 for observations, 1 for doses

EVID

Event ID

Details

The data were originally given in Grasela and Donn(1985) and are analyzed in Boeckmann, Sheiner and Beal (1994), in Davidian and Giltinan (1995), and in Littell et al. (1996).