Convert fit to FOCEi style fit
Covariance matrix by Fisher Information Matrix via linearization
SAEM dll prodection from garbage collection
Generate an SAEM model
Sets nodes and weigts of Gauss-Hermite quadrature
This gets the parsed data in the lower-level manner that nlmixr expects.
Log-likelihood using Gaussian Quadrature
nlmixr model block
Access the model list information for nlmixr's nlme user functions
Return composite nlme/focei to nlme
Control Options for FOCEi
Bootstrap data
Convert/Format the data appropriately for nlmixr
FOCEi fit
Fit/Evaulate FOCEi
Calculate gnlmm variance-covariance matrix of fixed effects
Return composite saem/focei to saem
1 Compartment Model w/ Michelis Menton Elimination
Change a nlmixr fit object to a huxtable
Clear memoise cache for nlmixr
Get the FOCEi theta or eta specification for model.
Cox Box, Yeo Johnson and inverse transformation
Fit a non-population dynamic model
Configure an SAEM model
Generalized Cholesky Matrix Decomposition
Fit a non-population dynamic model using mcmc
Construct RxODE linCmt function
Get the FOCEi initializations
Inverse Guassian absorption model
Create the nlme specs list for nlmixr nlme solving
concentrations from a linear compartment model
Get the eta->eta.trans for SAEM
GOF plots for nlme-based mixed-effect models
Calculate gnlmm variance-covariance matrix of random effects
Fit nlme-based linear compartment mixed-effect model using closed form solution
Predict a nlmixr solved system
Forward covariate selection for nlme-base non-linear mixed effect models
Print x using the message facility
Fit nlme-based mixed-effect model using ODE implementation
Return dynmodel variable translation function
Get parameters that are fixed
nlmixr fits population PK and PKPD non-linear mixed effects models.
Generate saem.fit user function.
Return RxODE model with predictions appended
nlmixrBounds.focei.upper.lower
Get upper/lower/names for THETAs
Get initial estimate for ares SAEM.
Generate SAEM initial estimates for THETA.
Get ETA names
SAEM's init$omega
Dispaly nlmixr's version
Fit a nlmixr model
Plot of a non-population dynamic model fit
Plot of a non-population dynamic model fit using mcmc
Get the Parameter function with THETA/ETAs defined
Nelder-Mead of simplex search
Validate nlmixr
Get model$log.eta for SAEM
Get a list of directories for inclusion
Objects exported from other packages
Pump failure example dataset
Plot a nlmixr data object
Generate SAEM model list
Get the SAEM model$res.mod code
Plot an SAEM model fit
nlmixrUI.saem.model.omega
Get the SAEM model Omega
Extract residuals from the FOCEI fit
Get the FOCEi theta specification for the model
Calculate Hessian
Parent/Metabolite dataset
Parameters for a linear compartment model for SAEM
Pregnant Rat Diet Experiment
Fit a generalized nonlinear mixed-effect model
instant.stan.extension.
Augmented Prediction for nlmixr fit
Messages the nlmixr logo...
nlmixr ini block handling
Cleanup saem_fit environment by removing dll after the object is no logner used by R.
Prediction after a gnlmm fit
Print a non-population dynamic model fit object
Fit an SAEM model
Extract the Nlmixr bound information from a function.
Get the optimal forward difference interval by Gill83 method
Control Options for SAEM
Create the nlme parameter transform function from the UI object.
Get the variance for the nlme fit process based on UI
Visual predictive check (VPC) for nlmixr nlme objects
Vpc function for nlmixr
Set Objective function type for a nlmixr object
Create a gradient function based on gill numerical differences
Single Dose Phenobarbitol PK/PD
Get saem initilization list
Convert data to RxODE format (depreciated)
Summary of a non-population dynamic model fit using mcmc
Prepares the UI function and returns a list.
Find the assignments in R expression
Get parameters that are fixed for SAEM
Get initial estimate for bres SAEM.
Return the objective function
Simulate a nlmixr solved system
Print an SAEM model fit summary
Output table/data.frame options
Print UI function
nlmixrUI.saem.distribution
Get SAEM distribution
Print an SAEM model fit summary
Warfarin PK/PD data
Multiple dose Theophilline PK data
Get error names for SAEM
Create a large output based on a nlmixr fit
Get THETA names for nlmixr's SAEM
Summary of a non-population dynamic model fit using mcmc
Create a run summary word document
Print a gnlmm fit
Produce trace-plot for fit if applicable
Multiple dose Theophilline PK data
Return the square root of general square matrix A
Summary of a non-population dynamic model fit
VPC based on ui model
VPC for nlmixr saemFit objects
NPDE calculation for nlmixr
Add CWRES
Return VarCorr for nlmixr nlme
Simulated Data Set for comparing objective functions
Bolus_1CPT -- 1 Compartment Model Simulated Data from ACOP 2016
2 Compartment Model
Infusion_1CPT -- 1 Compartment Model Simulated Data from ACOP 2016
Oral_1CPT -- 1 Compartment Model with Oral Absorption Simulated Data from ACOP 2016
2 Compartment Model with Michelis Menton Clearance