Simulated Data Set for comparing objective functions
Return VarCorr for nlmixr nlme
Add CWRES
NPDE calculation for nlmixr
2 Compartment Model
Calculate gnlmm variance-covariance matrix of fixed effects
Change a nlmixr fit object to a huxtable
Bootstrap data
2 Compartment Model with Michelis Menton Clearance
Return composite saem/focei to saem
Generalized Cholesky Matrix Decomposition
Cox Box, Yeo Johnson and inverse transformation
Bolus_1CPT -- 1 Compartment Model Simulated Data from ACOP 2016
Infusion_1CPT -- 1 Compartment Model Simulated Data from ACOP 2016
1 Compartment Model w/ Michelis Menton Elimination
Covariance matrix by Fisher Information Matrix via linearization
Oral_1CPT -- 1 Compartment Model with Oral Absorption Simulated Data from ACOP 2016
Fit a non-population dynamic model
Log-likelihood using Gaussian Quadrature
Fit a non-population dynamic model using mcmc
This gets the parsed data in the lower-level manner that nlmixr expects.
SAEM dll prodection from garbage collection
Return composite nlme/focei to nlme
Convert fit to FOCEi style fit
Calculate gnlmm variance-covariance matrix of random effects
instant.stan.extension.
Get the FOCEi theta specification for the model
Fit a generalized nonlinear mixed-effect model
Control Options for FOCEi
nlmixr model block
Fit/Evaulate FOCEi
Get the FOCEi theta or eta specification for model.
nlmixr ini block handling
Configure an SAEM model
Construct RxODE linCmt function
Forward covariate selection for nlme-base non-linear mixed effect models
Convert/Format the data appropriately for nlmixr
Access the model list information for nlmixr's nlme user functions
FOCEi fit
Simulate a nlmixr solved system
Clear memoise cache for nlmixr
Extract the Nlmixr bound information from a function.
Augmented Prediction for nlmixr fit
nlmixrBounds.focei.upper.lower
Get upper/lower/names for THETAs
Get parameters that are fixed
nlmixr fits population PK and PKPD non-linear mixed effects models.
Get ETA names
Fit nlme-based mixed-effect model using ODE implementation
Return dynmodel variable translation function
Get the optimal forward difference interval by Gill83 method
Create a gradient function based on gill numerical differences
Get model$log.eta for SAEM
Return RxODE model with predictions appended
Get initial estimate for ares SAEM.
Sets nodes and weigts of Gauss-Hermite quadrature
Generate an SAEM model
Parameters for a linear compartment model for SAEM
Get THETA names for nlmixr's SAEM
Get saem initilization list
Get parameters that are fixed for SAEM
Get error names for SAEM
SAEM's init$omega
Prepares the UI function and returns a list.
Generate SAEM initial estimates for THETA.
Parent/Metabolite dataset
concentrations from a linear compartment model
Dispaly nlmixr's version
Inverse Guassian absorption model
GOF plots for nlme-based mixed-effect models
Calculate Hessian
Fit nlme-based linear compartment mixed-effect model using closed form solution
Messages the nlmixr logo...
Get the variance for the nlme fit process based on UI
Generate SAEM model list
Predict a nlmixr solved system
Create the nlme parameter transform function from the UI object.
Get initial estimate for bres SAEM.
Plot a nlmixr data object
Get the FOCEi initializations
Get the Parameter function with THETA/ETAs defined
Create the nlme specs list for nlmixr nlme solving
nlmixrUI.saem.distribution
Get SAEM distribution
Print x using the message facility
Validate nlmixr
Find the assignments in R expression
Convert data to RxODE format (depreciated)
Return the objective function
Get a list of directories for inclusion
Summary of a non-population dynamic model fit
Nelder-Mead of simplex search
Print an SAEM model fit summary
Print UI function
Return the square root of general square matrix A
Single Dose Phenobarbitol PK/PD
Pump failure example dataset
Pregnant Rat Diet Experiment
Get the eta->eta.trans for SAEM
Output table/data.frame options
Multiple dose Theophilline PK data
Cleanup saem_fit environment by removing dll after the object is no logner used by R.
Prediction after a gnlmm fit
Warfarin PK/PD data
Print a non-population dynamic model fit object
Fit an SAEM model
Plot an SAEM model fit
Fit a nlmixr model
Create a run summary word document
Create a large output based on a nlmixr fit
Vpc function for nlmixr
Summary of a non-population dynamic model fit using mcmc
Control Options for SAEM
Set Objective function type for a nlmixr object
Print a gnlmm fit
Produce trace-plot for fit if applicable
Multiple dose Theophilline PK data
Visual predictive check (VPC) for nlmixr nlme objects
Generate saem.fit user function.
Get the SAEM model$res.mod code
nlmixrUI.saem.model.omega
Get the SAEM model Omega
Plot of a non-population dynamic model fit
Extract residuals from the FOCEI fit
Plot of a non-population dynamic model fit using mcmc
Objects exported from other packages
Summary of a non-population dynamic model fit using mcmc
Print an SAEM model fit summary
VPC for nlmixr saemFit objects
VPC based on ui model