Log-likelihood using Gaussian Quadrature
Covariance matrix by Fisher Information Matrix via linearization
Fit a non-population dynamic model
Fit a non-population dynamic model using mcmc
Return composite nlme/focei to nlme
Forward covariate selection for nlme-base non-linear mixed effect models
Convert fit to FOCEi style fit
Configure an SAEM model
Calculate gnlmm variance-covariance matrix of fixed effects
Construct RxODE linCmt function
Fit/Evaulate FOCEi
nlmixr ini block handling
Extract the Nlmixr bound information from a function.
Augmented Prediction for nlmixr fit
instant.stan.extension.
Fit nlme-based mixed-effect model using ODE implementation
Predict a nlmixr solved system
nlmixr fits population PK and PKPD non-linear mixed effects models.
Clear memoise cache for nlmixr
Simulated Data Set for comparing objective functions
Return composite saem/focei to saem
Bootstrap data
Get the FOCEi theta specification for the model
Get the FOCEi theta or eta specification for model.
Cox Box, Yeo Johnson and inverse transformation
Get the eta->eta.trans for SAEM
concentrations from a linear compartment model
Convert/Format the data appropriately for nlmixr
Generalized Cholesky Matrix Decomposition
Change a nlmixr fit object to a huxtable
SAEM dll prodection from garbage collection
This gets the parsed data in the lower-level manner that nlmixr expects.
Calculate gnlmm variance-covariance matrix of random effects
Fit a generalized nonlinear mixed-effect model
Control Options for FOCEi
Generate an SAEM model
Print UI function
Sets nodes and weigts of Gauss-Hermite quadrature
Multiple dose Theophilline PK data
FOCEi fit
GOF plots for nlme-based mixed-effect models
Print x using the message facility
Get the FOCEi initializations
Simulate a nlmixr solved system
Multiple dose Theophilline PK data
Create a gradient function based on gill numerical differences
Fit nlme-based linear compartment mixed-effect model using closed form solution
Get the optimal forward difference interval by Gill83 method
Create the nlme specs list for nlmixr nlme solving
Calculate Hessian
Get the variance for the nlme fit process based on UI
nlmixrUI.saem.model.omega
Get the SAEM model Omega
Inverse Guassian absorption model
Get model$log.eta for SAEM
Get parameters that are fixed
Generate SAEM model list
Convert data to RxODE format (depreciated)
Return dynmodel variable translation function
Get THETA names for nlmixr's SAEM
SAEM's init$omega
Get parameters that are fixed for SAEM
Print a non-population dynamic model fit object
Plot of a non-population dynamic model fit
Generate SAEM initial estimates for THETA.
Get error names for SAEM
Create the nlme parameter transform function from the UI object.
Parameters for a linear compartment model for SAEM
Get ETA names
Summary of a non-population dynamic model fit using mcmc
Print a gnlmm fit
Nelder-Mead of simplex search
VPC for nlmixr saemFit objects
nlmixrBounds.focei.upper.lower
Get upper/lower/names for THETAs
Parent/Metabolite dataset
Get a list of directories for inclusion
Get the Parameter function with THETA/ETAs defined
Get initial estimate for bres SAEM.
Prepares the UI function and returns a list.
Fit a nlmixr model
Dispaly nlmixr's version
Create a large output based on a nlmixr fit
Create a run summary word document
Generate saem.fit user function.
Validate nlmixr
Warfarin PK/PD data
Objects exported from other packages
Cleanup saem_fit environment by removing dll after the object is no logner used by R.
Fit an SAEM model
Return RxODE model with predictions appended
Messages the nlmixr logo...
Get initial estimate for ares SAEM.
nlmixr model block
Access the model list information for nlmixr's nlme user functions
Get the SAEM model$res.mod code
Plot of a non-population dynamic model fit using mcmc
Prediction after a gnlmm fit
Vpc function for nlmixr
Pump failure example dataset
VPC based on ui model
Return the square root of general square matrix A
Visual predictive check (VPC) for nlmixr nlme objects
Summary of a non-population dynamic model fit
Extract residuals from the FOCEI fit
Summary of a non-population dynamic model fit using mcmc
Print an SAEM model fit summary
Get saem initilization list
Plot an SAEM model fit
nlmixrUI.saem.distribution
Get SAEM distribution
Set Objective function type for a nlmixr object
Return the objective function
Plot a nlmixr data object
Pregnant Rat Diet Experiment
Control Options for SAEM
Single Dose Phenobarbitol PK/PD
Produce trace-plot for fit if applicable
Print an SAEM model fit summary
Output table/data.frame options
Find the assignments in R expression
Bolus_1CPT -- 1 Compartment Model Simulated Data from ACOP 2016
1 Compartment Model w/ Michelis Menton Elimination
2 Compartment Model with Michelis Menton Clearance
2 Compartment Model
Add CWRES
NPDE calculation for nlmixr
Oral_1CPT -- 1 Compartment Model with Oral Absorption Simulated Data from ACOP 2016
Infusion_1CPT -- 1 Compartment Model Simulated Data from ACOP 2016
Return VarCorr for nlmixr nlme