NPDE calculation for nlmixr
Return VarCorr for nlmixr nlme
2 Compartment Model
Add CWRES
Calculate gnlmm variance-covariance matrix of fixed effects
Bootstrap data
Simulated Data Set for comparing objective functions
Bolus_1CPT -- 1 Compartment Model Simulated Data from ACOP 2016
Oral_1CPT -- 1 Compartment Model with Oral Absorption Simulated Data from ACOP 2016
Infusion_1CPT -- 1 Compartment Model Simulated Data from ACOP 2016
2 Compartment Model with Michelis Menton Clearance
Return composite saem/focei to saem
Control Options for FOCEi
Generalized Cholesky Matrix Decomposition
FOCEi fit
Cox Box, Yeo Johnson and inverse transformation
Configure an SAEM model
Calculate gnlmm variance-covariance matrix of random effects
Construct RxODE linCmt function
Log-likelihood using Gaussian Quadrature
Change a nlmixr fit object to a huxtable
Covariance matrix by Fisher Information Matrix via linearization
This gets the parsed data in the lower-level manner that nlmixr expects.
nlmixr ini block handling
SAEM dll prodection from garbage collection
instant.stan.extension.
Get the FOCEi theta or eta specification for model.
Parameters for a linear compartment model for SAEM
Convert fit to FOCEi style fit
Return composite nlme/focei to nlme
Fit a generalized nonlinear mixed-effect model
nlmixr model block
Get ETA names
Get the FOCEi theta specification for the model
1 Compartment Model w/ Michelis Menton Elimination
Fit a non-population dynamic model
Parent/Metabolite dataset
Fit a non-population dynamic model using mcmc
Generate an SAEM model
Sets nodes and weigts of Gauss-Hermite quadrature
GOF plots for nlme-based mixed-effect models
nlmixrBounds.focei.upper.lower
Get upper/lower/names for THETAs
Forward covariate selection for nlme-base non-linear mixed effect models
Fit/Evaulate FOCEi
Access the model list information for nlmixr's nlme user functions
Fit nlme-based mixed-effect model using ODE implementation
Print x using the message facility
concentrations from a linear compartment model
Augmented Prediction for nlmixr fit
Get the FOCEi initializations
Create the nlme specs list for nlmixr nlme solving
Predict a nlmixr solved system
Return dynmodel variable translation function
Inverse Guassian absorption model
Get the eta->eta.trans for SAEM
Get the optimal forward difference interval by Gill83 method
Generate saem.fit user function.
Extract the Nlmixr bound information from a function.
Create a gradient function based on gill numerical differences
Fit nlme-based linear compartment mixed-effect model using closed form solution
Get the variance for the nlme fit process based on UI
Create the nlme parameter transform function from the UI object.
Find the assignments in R expression
Get initial estimate for bres SAEM.
nlmixrUI.saem.distribution
Get SAEM distribution
Simulate a nlmixr solved system
Get error names for SAEM
Convert/Format the data appropriately for nlmixr
Clear memoise cache for nlmixr
Get model$log.eta for SAEM
Prepares the UI function and returns a list.
nlmixr fits population PK and PKPD non-linear mixed effects models.
Dispaly nlmixr's version
Print a gnlmm fit
Generate SAEM model list
Control Options for SAEM
Summary of a non-population dynamic model fit using mcmc
Plot an SAEM model fit
Plot a nlmixr data object
Fit a nlmixr model
Calculate Hessian
Convert data to RxODE format (depreciated)
Get THETA names for nlmixr's SAEM
Return the objective function
Get initial estimate for ares SAEM.
SAEM's init$omega
Get the SAEM model$res.mod code
Messages the nlmixr logo...
Return RxODE model with predictions appended
nlmixrUI.saem.model.omega
Get the SAEM model Omega
Generate SAEM initial estimates for THETA.
Nelder-Mead of simplex search
Get parameters that are fixed
Get a list of directories for inclusion
Create a run summary word document
Get parameters that are fixed for SAEM
Objects exported from other packages
Single Dose Phenobarbitol PK/PD
Summary of a non-population dynamic model fit
Print UI function
Print an SAEM model fit summary
Return the square root of general square matrix A
Vpc function for nlmixr
Set Objective function type for a nlmixr object
Get saem initilization list
Extract residuals from the FOCEI fit
Validate nlmixr
Get the Parameter function with THETA/ETAs defined
Visual predictive check (VPC) for nlmixr nlme objects
Plot of a non-population dynamic model fit
Print an SAEM model fit summary
Summary of a non-population dynamic model fit using mcmc
Create a large output based on a nlmixr fit
Prediction after a gnlmm fit
Plot of a non-population dynamic model fit using mcmc
VPC for nlmixr saemFit objects
VPC based on ui model
Output table/data.frame options
Print a non-population dynamic model fit object
Cleanup saem_fit environment by removing dll after the object is no logner used by R.
Fit an SAEM model
Produce trace-plot for fit if applicable
Multiple dose Theophilline PK data
Multiple dose Theophilline PK data
Pump failure example dataset
Warfarin PK/PD data
Pregnant Rat Diet Experiment