getOmegas

This function constructs a combined table containing:<ul>
<li>ETA variances (e.g., <code>eta.cl</code>, <code>eta.vc</code>), which represent inter-individual variability (IIV) in pharmacokinetic parameters;</li>
<li>Derived covariances (e.g., <code>cov.eta_cl_vc</code>) computed from ETA variances and assumed pairwise correlations.</li>
</ul>

Provides automated methods for generating initial parameter estimates
in population pharmacokinetic modeling. The pipeline integrates adaptive single-point
methods, naive pooled graphic approaches, noncompartmental analysis methods, and parameter
sweeping across pharmacokinetic models. It estimates residual unexplained variability
using either data-driven or fixed-fraction approaches and assigns pragmatic initial values
for inter-individual variability. These strategies are designed to improve model
robustness and convergence in 'nlmixr2' workflows. For more details see
Huang Z, Fidler M, Lan M, Cheng IL, Kloprogge F, Standing JF (2025)
<doi:10.1007/s10928-025-10000-z>.

getOmegas: Generate ETA variance and covariance table

Description

Usage

Arguments

Value

Details

Examples