graphcal_iv

Estimates clearance (CL), volume of distribution (Vd), terminal slope
(lambdaz), and extrapolated concentration at time zero (C0exp) from
intravenous pharmacokinetic data using graphical methods.

Provides automated methods for generating initial parameter estimates
in population pharmacokinetic modeling. The pipeline integrates adaptive single-point
methods, naive pooled graphic approaches, noncompartmental analysis methods, and parameter
sweeping across pharmacokinetic models. It estimates residual unexplained variability
using either data-driven or fixed-fraction approaches and assigns pragmatic initial values
for inter-individual variability. These strategies are designed to improve model
robustness and convergence in 'nlmixr2' workflows. For more details see
Huang Z, Fidler M, Lan M, Cheng IL, Kloprogge F, Standing JF (2025)
<doi:10.1007/s10928-025-10000-z>.

Zhonghui Huang

nlmixr2autoinit

Automatic Generation of Initial Estimates for Population
Pharmacokinetic Modeling

Joseph Standing

Matthew Fidler

Frank Kloprogge

graphcal_iv function

<dl><dt>dat</dt>
<dd>A data frame containing TIME (time after dosing) and DV
(observed concentration).</dd>
<dt>dose</dt>
<dd>Administered dose amount. Defaults to 1.</dd>
<dt>...</dt>
<dd>Additional arguments passed to <code>force_find_lambdaz()</code>.</dd></dl>

Arguments

Author

Graphical calculation of clearance and volume of distribution (IV route) — graphcal_iv

<dl>

<dt>dat</dt>
<dd>A data frame containing TIME (time after dosing) and DV
(observed concentration).</dd>


<dt>dose</dt>
<dd>Administered dose amount. Defaults to 1.</dd>


<dt>...</dt>
<dd>Additional arguments passed to <code>force_find_lambdaz()</code>.</dd>

</dl>

graphcal_iv: Graphical calculation of clearance and volume of distribution (IV route)

Description

Usage

Value

Arguments

Author

Details

See Also

Examples