nlmixr2autoinit (version 1.0.0)

run_npd_1cmpt_iv: Run and evaluate a one-compartment IV model

Description

Fits a one-compartment intravenous pharmacokinetic model using a naive pooled data approach and evaluates model performance based on prediction error metrics.

Usage

run_npd_1cmpt_iv(
  dat,
  est.method = "nls",
  input.cl = exp(1),
  input.vd = exp(1),
  input.add = 1
)

Value

A list containing the fitted parameter estimates and prediction error metrics.

Arguments

dat

A data frame containing raw time–concentration data in standard nlmixr2 format.

est.method

Estimation method used in nlmixr2. Defaults to "nls".

input.cl

Initial estimate for clearance (CL). Defaults to exp(1), corresponding to a log-scale value of 1.

input.vd

Initial estimate for volume of distribution (Vd). Defaults to exp(1), corresponding to a log-scale value of 1.

input.add

Additive error term. Defaults to 1.

Author

Zhonghui Huang

Details

Rows with EVID == 2 are excluded prior to model fitting. The model is fitted using Fit_1cmpt_iv, and prediction-based metrics are calculated to assess performance.

See Also

Fit_1cmpt_iv

Examples

# \donttest{
run_npd_1cmpt_iv(dat = Bolus_1CPT, input.cl = 4, input.vd = 70)
# }