Constructs a list of control parameters used by is_ss() to determine pharmacokinetic steady state.
ss_control(
ss_method = c("combined", "fixed_doses", "half_life_based"),
no.doses = 5,
no.half_lives = 5,
allowed_interval_variation = 0.25,
allowed_dose_variation = 0.2,
min_doses_required = 3,
tad_rounding = TRUE
)A named list containing the steady-state control parameters,
typically passed as the ssctrl argument to is_ss().
Character string specifying the method used to determine steady state. One of:
"combined" (default): uses the smaller of the dose-based estimate (no.doses) and the half-life-based estimate (no.half_lives)
"fixed_doses": considers steady state reached after no.doses administrations
"half_life_based": uses the drug half-life and dosing interval to estimate the required number of doses
Integer indicating the number of doses assumed necessary to reach steady state when using the "fixed_doses" method or as part of the "combined" method. Default is 5.
Integer indicating the number of half-lives required to reach steady state when using the "half_life_based" or "combined" method. Default is 5.
Numeric value specifying the acceptable fractional variation in dose interval. For example, 0.25 allows plus or minus 25 percent variation. Default is 0.25.
Numeric value specifying the acceptable fractional variation in dose amount. For example, 0.20 allows plus or minus 20 percent variation. Default is 0.20.
Integer specifying the minimum number of doses that must be administered regardless of method. Default is 3.
Logical value. If TRUE (default), rounding is applied when comparing time after dose (tad) to dosing intervals to allow small numerical deviations.
is_ss
ss_control()
ss_control(ss_method = "fixed_doses", no.doses = 4)
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