trimmed_geom_mean

Computes the trimmed geometric mean of a numeric vector

Provides automated methods for generating initial parameter estimates
in population pharmacokinetic modeling. The pipeline integrates adaptive single-point
methods, naive pooled graphic approaches, noncompartmental analysis methods, and parameter
sweeping across pharmacokinetic models. It estimates residual unexplained variability
using either data-driven or fixed-fraction approaches and assigns pragmatic initial values
for inter-individual variability. These strategies are designed to improve model
robustness and convergence in 'nlmixr2' workflows. For more details see
Huang Z, Fidler M, Lan M, Cheng IL, Kloprogge F, Standing JF (2025)
<doi:10.1007/s10928-025-10000-z>.

Zhonghui Huang

nlmixr2autoinit

Automatic Generation of Initial Estimates for Population
Pharmacokinetic Modeling

Joseph Standing

Matthew Fidler

Frank Kloprogge

trimmed_geom_mean function

<dl><dt>x</dt>
<dd>A numeric vector containing the values for geometric mean
calculation.</dd>
<dt>trim</dt>
<dd>A numeric value between 0 and 0.5 indicating the proportion of
values to be trimmed from each end of the vector. Default is 0.</dd>
<dt>na.rm</dt>
<dd>Logical value indicating whether missing values should be
removed before computation. Default is TRUE.</dd></dl>

Arguments

Computes the trimmed geometric mean — trimmed_geom_mean

<dl>

<dt>x</dt>
<dd>A numeric vector containing the values for geometric mean
calculation.</dd>


<dt>trim</dt>
<dd>A numeric value between 0 and 0.5 indicating the proportion of
values to be trimmed from each end of the vector. Default is 0.</dd>


<dt>na.rm</dt>
<dd>Logical value indicating whether missing values should be
removed before computation. Default is TRUE.</dd>

</dl>

trimmed_geom_mean: Computes the trimmed geometric mean

Description

Usage

Value

Arguments

Examples