.nlmixrPreprocessLiteralFix

Whenever there is a fixed parameter in the model, the parameter is
replaced with the literal value inside of the model and dropped
from the `ini` block. This only occurs when the
`control$literalFix=TRUE`.

Fit and compare nonlinear mixed-effects models in
differential equations with flexible dosing information commonly seen
in pharmacokinetics and pharmacodynamics (Almquist, Leander, and
Jirstrand 2015 <doi:10.1007/s10928-015-9409-1>). Differential equation
solving is by compiled C code provided in the 'rxode2' package (Wang,
Hallow, and James 2015 <doi:10.1002/psp4.12052>).

Matthew Fidler

nlmixr2est

Nonlinear Mixed Effects Models in Population PK/PD, Estimation
Routines

Yuan Xiong

Rik Schoemaker

Justin Wilkins

Wenping Wang

Robert Leary

Mason McComb

Vipul Mann

Mirjam Trame

Mahmoud Abdelwahab

Teun Post

Richard Hooijmaijers

Hadley Wickham

Dirk Eddelbuettel

Johannes Pfeifer

Robert B. Schnabel

Elizabeth Eskow

Emmanuelle Comets

Audrey Lavenu

Marc Lavielle

David Ardia

Katharine Mullen

Ben Goodrich

.nlmixrPreprocessLiteralFix function

<dl><dt>ui</dt>
<dd>model function/object</dd>
<dt>est</dt>
<dd>estimation method (all methods are shown by
`nlmixr2AllEst()`). Methods can be added for other tools</dd>
<dt>data</dt>
<dd>nlmixr data</dd>
<dt>control</dt>
<dd>The estimation control object. These are expected
to be different for each type of estimation method</dd></dl>

Arguments

Author

This literally fixes parameters in the model — .nlmixrPreprocessLiteralFix

<dl>

<dt>ui</dt>
<dd>model function/object</dd>


<dt>est</dt>
<dd>estimation method (all methods are shown by
`nlmixr2AllEst()`). Methods can be added for other tools</dd>


<dt>data</dt>
<dd>nlmixr data</dd>


<dt>control</dt>
<dd>The estimation control object. These are expected
to be different for each type of estimation method</dd>

</dl>

This literally fixes parameters in the model

.nlmixrPreprocessLiteralFix: This literally fixes parameters in the model

Description

Usage

Value

Arguments

Author