foControl

This is related to the focei methods and uses most of their control
options. Some are ignored, `posthoc` is an extra parameter

Fit and compare nonlinear mixed-effects models in
differential equations with flexible dosing information commonly seen
in pharmacokinetics and pharmacodynamics (Almquist, Leander, and
Jirstrand 2015 <doi:10.1007/s10928-015-9409-1>). Differential equation
solving is by compiled C code provided in the 'rxode2' package (Wang,
Hallow, and James 2015 <doi:10.1002/psp4.12052>).

Matthew Fidler

nlmixr2est

Nonlinear Mixed Effects Models in Population PK/PD, Estimation
Routines

Yuan Xiong

Rik Schoemaker

Justin Wilkins

Wenping Wang

Robert Leary

Mason McComb

Vipul Mann

Mirjam Trame

Mahmoud Abdelwahab

Teun Post

Richard Hooijmaijers

Hadley Wickham

Dirk Eddelbuettel

Johannes Pfeifer

Robert B. Schnabel

Elizabeth Eskow

Emmanuelle Comets

Audrey Lavenu

Marc Lavielle

David Ardia

Katharine Mullen

Ben Goodrich

foControl function

<dl><dt>sigdig</dt>
<dd>Optimization significant digits. This controls:
<ul>
<li>The tolerance of the inner and outer optimization is <code>10^-sigdig</code></li>
<li>The tolerance of the ODE solvers is
 <code>0.5*10^(-sigdig-2)</code>; For the sensitivity equations and
 steady-state solutions the default is <code>0.5*10^(-sigdig-1.5)</code>
 (sensitivity changes only applicable for liblsoda)</li>
<li>The tolerance of the boundary check is <code>5 * 10 ^ (-sigdig + 1)</code></li>
</ul></dd>
<dt>...</dt>
<dd>Parameters used in the default `foceiConrol()`</dd>
<dt>posthoc</dt>
<dd>Logical indicating if the estimation method should
calculate `foce` posthoc predicted parameters.</dd>
<dt>interaction</dt>
<dd>Interaction term for the model; ignored by fo</dd>
<dt>fo</dt>
<dd>Logical indicating if the estimation method is FO (first
order), but this is controlled by the estimation method so this
is ignored.</dd></dl>

Arguments

Author

Control options for the FO estimation method — foControl

<dl>

<dt>sigdig</dt>
<dd>Optimization significant digits. This controls:
<ul>
<li>The tolerance of the inner and outer optimization is <code>10^-sigdig</code></li>
<li>The tolerance of the ODE solvers is
 <code>0.5*10^(-sigdig-2)</code>; For the sensitivity equations and
 steady-state solutions the default is <code>0.5*10^(-sigdig-1.5)</code>
 (sensitivity changes only applicable for liblsoda)</li>
<li>The tolerance of the boundary check is <code>5 * 10 ^ (-sigdig + 1)</code></li>
</ul></dd>


<dt>...</dt>
<dd>Parameters used in the default `foceiConrol()`</dd>


<dt>posthoc</dt>
<dd>Logical indicating if the estimation method should
calculate `foce` posthoc predicted parameters.</dd>


<dt>interaction</dt>
<dd>Interaction term for the model; ignored by fo</dd>


<dt>fo</dt>
<dd>Logical indicating if the estimation method is FO (first
order), but this is controlled by the estimation method so this
is ignored.</dd>

</dl>

Control options for the FO estimation method

foControl: Control options for the FO estimation method

Description

Usage

Value

Arguments

Author

Examples