nmsimplex

Fit and compare nonlinear mixed-effects models in
differential equations with flexible dosing information commonly seen
in pharmacokinetics and pharmacodynamics (Almquist, Leander, and
Jirstrand 2015 <doi:10.1007/s10928-015-9409-1>). Differential equation
solving is by compiled C code provided in the 'rxode2' package (Wang,
Hallow, and James 2015 <doi:10.1002/psp4.12052>).

Matthew Fidler

nlmixr2est

Nonlinear Mixed Effects Models in Population PK/PD, Estimation
Routines

Yuan Xiong

Rik Schoemaker

Justin Wilkins

Wenping Wang

Robert Leary

Mason McComb

Vipul Mann

Mirjam Trame

Mahmoud Abdelwahab

Teun Post

Richard Hooijmaijers

Hadley Wickham

Dirk Eddelbuettel

Johannes Pfeifer

Robert B. Schnabel

Elizabeth Eskow

Emmanuelle Comets

Audrey Lavenu

Marc Lavielle

David Ardia

Katharine Mullen

Ben Goodrich

nmsimplex function

<dl><dt>start</dt>
<dd>initials</dd>
<dt>fr</dt>
<dd>objective function</dd>
<dt>rho</dt>
<dd>evaluation environment</dd>
<dt>control</dt>
<dd>additional optimization options</dd></dl>

Arguments

Nelder-Mead simplex search — nmsimplex

<dl>

<dt>start</dt>
<dd>initials</dd>


<dt>fr</dt>
<dd>objective function</dd>


<dt>rho</dt>
<dd>evaluation environment</dd>


<dt>control</dt>
<dd>additional optimization options</dd>

</dl>

Nelder-Mead simplex search

nmsimplex: Nelder-Mead simplex search

Description

Usage

Value

Arguments