posthocControl

This option is for simply getting the maximum a-prior (MAP) also
called the posthoc estimates

Fit and compare nonlinear mixed-effects models in
differential equations with flexible dosing information commonly seen
in pharmacokinetics and pharmacodynamics (Almquist, Leander, and
Jirstrand 2015 <doi:10.1007/s10928-015-9409-1>). Differential equation
solving is by compiled C code provided in the 'rxode2' package (Wang,
Hallow, and James 2015 <doi:10.1002/psp4.12052>).

Matthew Fidler

nlmixr2est

Nonlinear Mixed Effects Models in Population PK/PD, Estimation
Routines

Yuan Xiong

Rik Schoemaker

Justin Wilkins

Wenping Wang

Robert Leary

Mason McComb

Vipul Mann

Mirjam Trame

Mahmoud Abdelwahab

Teun Post

Richard Hooijmaijers

Hadley Wickham

Dirk Eddelbuettel

Johannes Pfeifer

Robert B. Schnabel

Elizabeth Eskow

Emmanuelle Comets

Audrey Lavenu

Marc Lavielle

David Ardia

Katharine Mullen

Ben Goodrich

posthocControl function

<dl><dt>sigdig</dt>
<dd>Optimization significant digits. This controls:
<ul>
<li>The tolerance of the inner and outer optimization is <code>10^-sigdig</code></li>
<li>The tolerance of the ODE solvers is
 <code>0.5*10^(-sigdig-2)</code>; For the sensitivity equations and
 steady-state solutions the default is <code>0.5*10^(-sigdig-1.5)</code>
 (sensitivity changes only applicable for liblsoda)</li>
<li>The tolerance of the boundary check is <code>5 * 10 ^ (-sigdig + 1)</code></li>
</ul></dd>
<dt>...</dt>
<dd>Parameters used in the default `foceiConrol()`</dd>
<dt>interaction</dt>
<dd>Interaction term for the model, in this case the
default is `FALSE`, though you can set it to be `TRUE` as well.</dd>
<dt>maxOuterIterations</dt>
<dd>ignored, posthoc always sets this to 0.</dd></dl>

Arguments

Author

Control options for the posthoc estimation method — posthocControl

<dl>

<dt>sigdig</dt>
<dd>Optimization significant digits. This controls:
<ul>
<li>The tolerance of the inner and outer optimization is <code>10^-sigdig</code></li>
<li>The tolerance of the ODE solvers is
 <code>0.5*10^(-sigdig-2)</code>; For the sensitivity equations and
 steady-state solutions the default is <code>0.5*10^(-sigdig-1.5)</code>
 (sensitivity changes only applicable for liblsoda)</li>
<li>The tolerance of the boundary check is <code>5 * 10 ^ (-sigdig + 1)</code></li>
</ul></dd>


<dt>...</dt>
<dd>Parameters used in the default `foceiConrol()`</dd>


<dt>interaction</dt>
<dd>Interaction term for the model, in this case the
default is `FALSE`, though you can set it to be `TRUE` as well.</dd>


<dt>maxOuterIterations</dt>
<dd>ignored, posthoc always sets this to 0.</dd>

</dl>

Control options for the posthoc estimation method

posthocControl: Control options for the posthoc estimation method

Description

Usage

Value

Arguments

Author

Examples