profileFixed

profileFixedSingle

Estimate the objective function values for a model while fixing defined
parameter values

Fit and compare nonlinear mixed-effects models in
differential equations with flexible dosing information commonly seen
in pharmacokinetics and pharmacodynamics (Almquist, Leander, and
Jirstrand 2015 <doi:10.1007/s10928-015-9409-1>). Differential equation
solving is by compiled C code provided in the 'rxode2' package (Wang,
Hallow, and James 2015 <doi:10.1002/psp4.12052>). This package is for
support functions like preconditioned fits
<doi:10.1208/s12248-016-9866-5>, boostrap and stepwise covariate
selection.

Matthew Fidler

nlmixr2extra

Nonlinear Mixed Effects Models in Population PK/PD, Extra
Support Functions

Vipul Mann

Vishal Sarsani

Christian Bartels

Bill Denney

profileFixed function

<dl><dt>fitted</dt>
<dd>The fit model</dd>
<dt>which</dt>
<dd>A data.frame with column names of parameters to fix and values
of the fitted value to fix (one row only).</dd>
<dt>control</dt>
<dd>A list passed to <code>fixedControl()</code> (currently unused)</dd></dl>

Arguments

<ul>
<li><code>profileFixedSingle()</code>: Estimate the objective function value for a model
while fixing a single set of defined parameter values (for use in parameter
profiling)</li>
</ul>

Functions

Bill Denney (changed by Matt Fidler to take out R 4.1 specific code)

Author

Estimate the objective function values for a model while fixing defined
parameter values — profileFixed

<dl>

<dt>fitted</dt>
<dd>The fit model</dd>


<dt>which</dt>
<dd>A data.frame with column names of parameters to fix and values
of the fitted value to fix (one row only).</dd>


<dt>control</dt>
<dd>A list passed to <code>fixedControl()</code> (currently unused)</dd>

</dl>

profileFixed: Estimate the objective function values for a model while fixing defined parameter values

Description

Usage

Value

Arguments

Functions

Author

See Also