ExpandDoseHist

Expands compressed dosing records (ADDL/II) into individual dose records.

This shows how NONMEM(R) software works. NONMEM's classical
estimation methods like 'First Order(FO) approximation', 'First Order
Conditional Estimation(FOCE)', and 'Laplacian approximation' are explained.
Additionally, provides functions for post-run processing of NONMEM output
files, generating comprehensive PDF diagnostic reports including objective
function value analysis, parameter estimates, prediction diagnostics,
residual diagnostics, empirical Bayes estimate (EBE) analysis, input data
summary, and individual pharmacokinetic parameter distributions.

Kyun-Seop Bae

Understanding Nonlinear Mixed Effects Modeling for Population
Pharmacokinetics

ExpandDoseHist function

<dl><dt>DoseHistTab</dt>
<dd>data.frame with columns TIME, AMT, II, ADDL</dd></dl>

Arguments

Expand Dose History with ADDL/II Records — ExpandDoseHist

<dl>

<dt>DoseHistTab</dt>
<dd>data.frame with columns TIME, AMT, II, ADDL</dd>

</dl>

ExpandDoseHist: Expand Dose History with ADDL/II Records

Description

Usage

Value

Arguments