build_dose_records

Build NONMEM dose records from an EX-like data.frame.
EX must contain: SUBJID, DAT2, TIME, AMT, RATE.
Optional: CMT (defaults to <code>dose_cmt</code>).
Output rows have MDV = 1, DV = 0.

This shows how NONMEM(R) software works. NONMEM's classical
estimation methods like 'First Order(FO) approximation', 'First Order
Conditional Estimation(FOCE)', and 'Laplacian approximation' are explained.
Additionally, provides functions for post-run processing of NONMEM output
files, generating comprehensive PDF diagnostic reports including objective
function value analysis, parameter estimates, prediction diagnostics,
residual diagnostics, empirical Bayes estimate (EBE) analysis, input data
summary, and individual pharmacokinetic parameter distributions.

Kyun-Seop Bae

Understanding Nonlinear Mixed Effects Modeling for Population
Pharmacokinetics

build_dose_records function

<dl><dt>EX</dt>
<dd>data.frame with dose information.</dd>
<dt>dose_cmt</dt>
<dd>default compartment for dose records lacking a CMT column.</dd></dl>

Arguments

Build NONMEM Dose Records — build_dose_records

<dl>

<dt>EX</dt>
<dd>data.frame with dose information.</dd>


<dt>dose_cmt</dt>
<dd>default compartment for dose records lacking a CMT column.</dd>

</dl>

build_dose_records: Build NONMEM Dose Records

Description

Usage

Value

Arguments