merge_cov_locf

Merge time-varying covariate columns into a NM-style data.frame using LOCF
(with LOCB for records before the first source). Subjects/records still NA
after LOCF/LOCB can be filled with the column-wise median of <code>cov_df</code>.

This shows how NONMEM(R) software works. NONMEM's classical
estimation methods like 'First Order(FO) approximation', 'First Order
Conditional Estimation(FOCE)', and 'Laplacian approximation' are explained.
Additionally, provides functions for post-run processing of NONMEM output
files, generating comprehensive PDF diagnostic reports including objective
function value analysis, parameter estimates, prediction diagnostics,
residual diagnostics, empirical Bayes estimate (EBE) analysis, input data
summary, and individual pharmacokinetic parameter distributions.

Kyun-Seop Bae

Understanding Nonlinear Mixed Effects Modeling for Population
Pharmacokinetics

merge_cov_locf function

<dl><dt>nm</dt>
<dd>data.frame with key columns <code>subj_col</code>, <code>dat_col</code>,
<code>tim_col</code>.</dd>
<dt>cov_df</dt>
<dd>data.frame with <code>subj_col</code>, <code>time_col</code>, and one or
more value columns.</dd>
<dt>value_cols</dt>
<dd>character vector of value columns in <code>cov_df</code> to
bring into <code>nm</code>.</dd>
<dt>time_col</dt>
<dd>name of the time column in <code>cov_df</code>, parsed by
<code>parse_dtc</code>.</dd>
<dt>median_fb</dt>
<dd>logical. If TRUE (default), fill remaining NA values with
the column-wise median of <code>cov_df</code>.</dd>
<dt>verbose</dt>
<dd>logical. Print median fill counts. Default FALSE.</dd>
<dt>subj_col</dt>
<dd>subject ID column name. Default "SUBJID".</dd>
<dt>dat_col</dt>
<dd>date column name in <code>nm</code>. Default "DAT2".</dd>
<dt>tim_col</dt>
<dd>time column name in <code>nm</code>. Default "TIME".</dd></dl>

Arguments

Merge Time-Varying Covariates by LOCF — merge_cov_locf

<dl>

<dt>nm</dt>
<dd>data.frame with key columns <code>subj_col</code>, <code>dat_col</code>,
<code>tim_col</code>.</dd>


<dt>cov_df</dt>
<dd>data.frame with <code>subj_col</code>, <code>time_col</code>, and one or
more value columns.</dd>


<dt>value_cols</dt>
<dd>character vector of value columns in <code>cov_df</code> to
bring into <code>nm</code>.</dd>


<dt>time_col</dt>
<dd>name of the time column in <code>cov_df</code>, parsed by
<code>parse_dtc</code>.</dd>


<dt>median_fb</dt>
<dd>logical. If TRUE (default), fill remaining NA values with
the column-wise median of <code>cov_df</code>.</dd>


<dt>verbose</dt>
<dd>logical. Print median fill counts. Default FALSE.</dd>


<dt>subj_col</dt>
<dd>subject ID column name. Default "SUBJID".</dd>


<dt>dat_col</dt>
<dd>date column name in <code>nm</code>. Default "DAT2".</dd>


<dt>tim_col</dt>
<dd>time column name in <code>nm</code>. Default "TIME".</dd>

</dl>

merge_cov_locf: Merge Time-Varying Covariates by LOCF

Description

Usage

Value

Arguments