a simulated matrix of testing statistics
for GxE. Each row corresponds to a SNP in a set, and each column represents
a study.
X
a simulated matrix of filtering statistics for GxE. Each
row corresponds to a SNP, and each column represents a study.
R
a
simulated correlation matrix for testing (or filtering) statistics in a set
under the null. The testing statistics for SNPs in LD will be also
correlated. The correlations can be approximated by the LD matrix. We
resample SNP-level testing and filtering statistics from multivariate normal
distributions to calculate the null meta-analysis statistics.