onemap (version 2.0-1)

group: Assign markers to linkage groups

Description

Identifies linkage groups of markers, using results from two-point (pairwise) analysis and the transitive property of linkage.

Usage

group(input.seq, LOD=NULL, max.rf=NULL)
## S3 method for class 'group':
print(x, detailed=TRUE, \dots)

Arguments

input.seq

an object of class sequence.

LOD

a (positive) real number used as minimum LOD score (threshold) to declare linkage.

max.rf

a real number (usually smaller than 0.5) used as maximum recombination fraction to declare linkage.

x

an object of class group.

detailed

logical. If FALSE, only a small summary of the linkage groups is printed. If TRUE (default), the names of markers in each linkage group are also displayed.

...

further arguments, passed to other methods. Currently ignored.

Value

• Returns an object of class group, which is a list containing the following components:
• data.name
  name of the object of class outcross that contains the raw data.
• twopt
  name of the object of class rf.2ts used as input, i.e., containing information used to assign markers to linkage groups.
• marnames
  marker names, according to the input file.
• n.mar
  total number of markers.
• LOD
  minimum LOD Score to declare linkage.
• max.rf
  maximum recombination fraction to declare linkage.
• n.groups
  number of linkage groups found.
• groups
  number of the linkage group to which each marker is assigned.

Details

If the arguments specifying thresholds used to group markers, i.e., minimum LOD Score and maximum recombination fraction, are NULL (default), the values used are those contained in object input.seq. If not using NULL, the new values overridden the ones in object input.seq.

References

Lincoln, S. E., Daly, M. J. and Lander, E. S. (1993) Constructing genetic linkage maps with MAPMAKER/EXP Version 3.0: a tutorial and reference manual. A Whitehead Institute for Biomedical Research Technical Report.

See Also

rf.2pts and make.seq

Examples

data(example.out)
  twopts <- rf.2pts(example.out)
  
  all.data <- make.seq(twopts,"all")
  link_gr <- group(all.data)
  link_gr