getIntegral

Helper function that integrates over the optimal conditional error function. Used to find appropriate level constant.

internal

Design and analysis of confirmatory adaptive clinical trials using the optimal conditional error framework according to Brannath and Bauer (2004) <doi:10.1111/j.0006-341X.2004.00221.x>. An extension to the optimal conditional error function using interim estimates as described in Brannath and Dreher (2024) <doi:10.48550/arXiv.2402.00814> and functions to ensure that the resulting conditional error function is non-increasing are also available.

Morten Dreher

optconerrf

Optimal Monotone Conditional Error Functions

Werner Brannath

Cornelia Ursula Kunz

Johanna zur Verth

getIntegral function

<dl><dt>constant</dt>
<dd>Current value of the level constant for the optimal conditional error function, internally used as integral argument.</dd>
<dt>design</dt>
<dd>An object of class <code>TrialDesignOptimalConditionalError</code> created by <code>getDesignOptimalConditionalErrorFunction()</code>. Contains all necessary arguments to calculate the optimal conditional error function for the specified case.</dd></dl>

Arguments

Internal calculation of the integral over psi — getIntegral

<dl>

<dt>constant</dt>
<dd>Current value of the level constant for the optimal conditional error function, internally used as integral argument.</dd>


<dt>design</dt>
<dd>An object of class <code>TrialDesignOptimalConditionalError</code> created by <code>getDesignOptimalConditionalErrorFunction()</code>. Contains all necessary arguments to calculate the optimal conditional error function for the specified case.</dd>

</dl>

getIntegral: Internal calculation of the integral over psi

Description

Usage

Value

Arguments

Details