occupancy: Compute Drug Occupancy with Approximate Standard Errors
Description
Receptor occupancy is calculated from posititron emission tomography
(PET) data as the treatment-induced relative change in the
concentration of available (not occupied) receptors.Usage
occupancy(base, drug, baseSE = NULL, drugSE = NULL, base.drug.corr = 0)
Arguments
base
is the baseline binding potential (BPND).
drug
is the post-treatment binding potential (BPND).
baseSE
is the standard error for the baseline BPND.
drugSE
is the standard error for the post-treatment BPND.
base.drug.corr
is the user-specified correlation between
baseline and post-treatment binding potentials.
Value
- OCCis the percent drug occupancy.
- SEis the approximate standard error of the parameter estimate.
Details
Occupancy is calculated using the straightforward and well-known
formula. If the standard errors for the two binding potentials are
provided, then the delta method is used to approximate the standard
error for the estimate of occupancy.References
Cunningham VJ, Rabiner EA, Slifstein M, Laruelle M (2010). Measuring
drug occupancy in the absence of a reference region: the Lassen plot
re-visited, Journal of Cerebral Blood Flow & Metababolism,
30, 46-50.
Passchier J, Gee A, Willemsen A, Vaalburg W, van Waarde A (2002).
Measuring drug-related receptor occupancy with positron emission
tomography, Methods, 27, 278-286.