Learn R Programming

⚠️There's a newer version (1.1-6) of this package.Take me there.

paramlink (version 1.1-2)

Parametric Linkage and Other Pedigree Analysis in R

Description

A suite of tools for analysing pedigrees with marker data, including parametric linkage analysis, forensic computations, relatedness analysis and marker simulations. The core of the package is an implementation of the Elston-Stewart algorithm for pedigree likelihoods, extended to allow mutations as well as complex inbreeding. Features for linkage analysis include singlepoint LOD scores, power analysis, and multipoint analysis (the latter through a wrapper to the 'MERLIN' software). Forensic applications include exclusion probabilities, genotype distributions and conditional simulations. Data from the 'Familias' software can be imported and analysed in 'paramlink'. Finally, 'paramlink' offers many utility functions for creating, manipulating and plotting pedigrees with or without marker data (the actual plotting is done by the 'kinship2' package).

Copy Link

Version

Install

install.packages('paramlink')

Monthly Downloads

389

Version

1.1-2

License

GPL (>= 2)

Maintainer

Magnus Vigeland

Last Published

January 5th, 2018

Functions in paramlink (1.1-2)

IBDtriangle

IBD triangle plot
LR

Likelihood ratios of pedigree hypotheses
exclusionPower

Power of exclusion
is.linkdat

Is an object a linkdat object?
pedCreate

Create simple pedigrees
pedModify

Modify the pedigree of 'linkdat' objects
setAvailable

Functions for modifying availability vectors
setModel

Set, change or display the model parameters for 'linkdat' objects
linkres

S3 methods for class 'linkres'.
lod

Two-point LOD score
pedParts

Pedigree subsets
pedigreeLoops

Pedigree loops
setPlotLabels

Attach plot labels to a linkdat object
showInTriangle

Add points to the IBD triangle
transferMarkerdata

Transfer marker data
twoMarkerDistribution

Genotype probability distribution
dominant

Example pedigree for linkage analysis
examineKinships

Check pedigree for relationship errors
markers

Marker functions
mendelianCheck

Check for Mendelian errors
simpleSim

Unconditional marker simulation
toyped

Toy pedigree for linkage analysis
Xped

Example pedigree with X-linked disease pattern.
allGenotypes

Genotype combinations
linkageSim

Simulate markers linked to a disease locus.
linkdat

Linkdat objects
oneMarkerDistribution

Genotype probability distribution
paramlink-package

paramlink: Parametric Linkage and Other Pedigree Analysis in R
relatednessCoeff

Relatedness coefficients
relationLR

Relationship Likelihood Ratio
mergePed

Merge two pedigrees
merlin

MERLIN wrappers
likelihood

Pedigree likelihood
linkage.power

Power of a linkage study
as.data.frame.linkdat

linkdat to data.frame conversion
as.matrix.linkdat

linkdat to matrix conversion
randomPed

Random pedigree
twoloops

A consanguineous pedigree
readDatfile

Read dat file in LINKAGE format
plot.linkdat

Plot pedigrees with genotypes
plotPedList

Plot a list of pedigrees.
Familias2linkdat

Convert 'Familias' output to linkdat objects
IBDestimate

Relatedness estimation
lod.peaks

LOD score peaks
markerSim

Marker simulation