pastboon (version 0.1.4)

lac_operon_net: The lactose operon Boolean network

Description

The lactose operon (lac operon) Boolean network proposed by Veliz-Cuba and Stigler.

Usage

data(lac_operon_net)

Details

The data consists of an object lac_operon_net of the class BooleanNetwork (from the BoolNet package), describing the lac operon gene regulatory network with 10 genes and 3 inputs. The three inputs collectively indicate the concentration of glucose and lactose. Based on the synchronous update scheme, when extracellular glucose is available, the lac operon is OFF (having one steady-state attractor where all genes are OFF). Otherwise, depending on the extracellular lactose concentration, the operon will be OFF, bistable (having two attractors), or ON (all genes are ON).

References

Veliz-Cuba, A., & Stigler, B. (2011). Boolean models can explain bistability in the lac operon. Journal of computational biology, 18(6), 783-794.

Examples

# load the network
data(lac_operon_net)

# the network is stored in a variable called 'lac_operon_net'
print(lac_operon_net)