Summarize multiple probe sets targeting one gene into one
value for that gene. On most microarays there will be
more than one probe set for a gene. However, in the
underlying network the gene will only be present one
time. Therefore, in order to calculate a Gene(Page)Rank
weight for this gene, all expression measurements have to
be summarized.
$n x p$ matrix with $n$
probe sets and $p$ samples.
mapping
a matrix or data.frame with 2 columns. The
colnames of mapping have to contain at least 'graphID'
and 'probesetID'. These two columns define the mapping
between the probe sets on the microarray and the nodes of
the graph.
method
defines how several probe sets should be
combined. One of median, mean,
foldChange or none.
groups
defines the grouping of samples. Only
needed if method is foldChange.
adjacency
a matrix that represents the graph of
the underlying biological network.
Value
matrix with 1st comlumn probeIDs 2nd column gene IDs
Details
summarizes all probes of a gene to one value for that
gene if the summarization method is 'none' then the only
thing which is done is that all probesets for which no
pathway is available are discarded.