get_biogrid_pin

organism name. BioGRID naming requires underscores for spaces so
"Homo sapiens" becomes "Homo_sapiens", "Mus musculus" becomes "Mus_musculus"
etc. See <a href="https://wiki.thebiogrid.org/doku.php/statistics">https://wiki.thebiogrid.org/doku.php/statistics</a> for a full
list of available organisms (default = "Homo_sapiens")

the path of the file to save the PIN data. By default, the
PIN data is saved in a temporary file

path2pin

the requested BioGRID release (default = "LATEST")

release

Retrieve the Requested Release of Organism-specific BioGRID PIN

Enrichment analysis enables researchers to uncover mechanisms
underlying a phenotype. However, conventional methods for enrichment
analysis do not take into account protein-protein interaction information,
resulting in incomplete conclusions. pathfindR is a tool for enrichment
analysis utilizing active subnetworks. The main function identifies active
subnetworks in a protein-protein interaction network using a user-provided
list of genes and associated p values. It then performs enrichment analyses
on the identified subnetworks, identifying enriched terms (i.e. pathways or,
more broadly, gene sets) that possibly underlie the phenotype of interest.
pathfindR also offers functionalities to cluster the enriched terms and
identify representative terms in each cluster, to score the enriched terms
per sample and to visualize analysis results. The enrichment, clustering and
other methods implemented in pathfindR are described in detail in
Ulgen E, Ozisik O, Sezerman OU. 2019. pathfindR: An R Package for
Comprehensive Identification of Enriched Pathways in Omics Data Through
Active Subnetworks. Front. Genet. <doi:10.3389/fgene.2019.00858>.

Ege Ulgen

pathfindR

Enrichment Analysis Utilizing Active Subnetworks

Ozan Ozisik

get_biogrid_pin function

organism name. BioGRID naming requires underscores for spaces so
"Homo sapiens" becomes "Homo_sapiens", "Mus musculus" becomes "Mus_musculus"
etc. See <a href='https://wiki.thebiogrid.org/doku.php/statistics'>https://wiki.thebiogrid.org/doku.php/statistics</a> for a full
list of available organisms (default = "Homo_sapiens")

get_biogrid_pin: Retrieve the Requested Release of Organism-specific BioGRID PIN

Description

Usage

Arguments

Value