mut_matrix

<p>mut_matrix, the mutations matrix,generated by `get_mut_matrix`</p>

datasets

A systematic bioinformatics tool to develop a new pathway-based gene panel for tumor mutational burden (TMB) assessment (pathway-based tumor mutational burden, PTMB), using somatic mutations files in an efficient manner from either The Cancer Genome Atlas sources or any in-house studies as long as the data is in mutation annotation file (MAF) format. Besides, we develop a multiple machine learning method using the sample's PTMB profiles to identify cancer-specific dysfunction pathways, which can be a biomarker of prognostic and predictive for cancer immunotherapy.

Junwei Han

pathwayTMB

Pathway Based Tumor Mutational Burden

Xiangmei Li

mut_matrix function

<p>An object of class <code>matrix</code> (inherits from <code>array</code>) with 673 rows and 35 columns.</p>

mut_matrix: mut_matrix, mutations matrix

Description

Usage

Arguments

Format