phase12designs (version 0.3.1)
Comprehensive Tools for Running Model-Assisted Phase I/II Trial
Simulations
Description
Provides a comprehensive set of tools to simulate, evaluate, and compare model-assisted designs for early-phase (Phase I/II) clinical trials, including:
- BOIN12 (Bayesian optimal interval phase 1/11 trial design; Lin et al. (2020) ),
- BOIN-ET (Takeda, K., Taguri, M., & Morita, S. (2018) ),
- EffTox (Thall, P. F., & Cook, J. D. (2004) ),
- Ji3+3 (Joint i3+3 design; Lin, X., & Ji, Y. (2020) ),
- PRINTE (probability intervals of toxicity and efficacy design; Lin, X., & Ji, Y. (2021) ),
- STEIN (simple toxicity and efficacy interval design; Lin, R., & Yin, G. (2017) ),
- TEPI (toxicity and efficacy probability interval design; Li, D. H., Whitmore, J. B., Guo, W., & Ji, Y. (2017) ),
- uTPI (utility-based toxicity Probability interval design; Shi, H., Lin, R., & Lin, X. (2024) ).
Includes flexible simulation parameters that allow
researchers to efficiently compute operating characteristics under
various fixed and random trial scenarios and export the results.