patlist_sim

The data "patlist_sim" is a trial generated by "SimPRMD". The model utilized
for generating trial is a 3-stage model with individualized dose modification.
The MTD = 4 and the MED = 1 since the dose-efficacy pattern when generating
the trial was set to be flat. The dose-toxicity trend and efficacy-cycle trend
are flat. There are in total 12 cohorts with 3 patients in each cohort. This
also serves as an example of the input data of function <code><a rd-options="" href="/link/RunPRMD?package=phase1PRMD&version=1.0.2" data-mini-rdoc="phase1PRMD::RunPRMD">RunPRMD</a></code>.

datasets

Implements Bayesian phase I repeated measurement design that
accounts for multidimensional toxicity endpoints and longitudinal efficacy
measure from multiple treatment cycles. The package provides flags to
fit a variety of model-based phase I design, including 1 stage models with
or without individualized dose modification, 3-stage models with or without
individualized dose modification, etc. Functions are provided to recommend
dosage selection based on the data collected in the available patient cohorts
and to simulate trial characteristics given design parameters.
Yin, Jun, et al. (2017) <doi:10.1002/sim.7134>.

Lu Zhang

phase1PRMD

Personalized Repeated Measurement Design for Phase I Clinical
Trials

patlist_sim function

An object of class <code>list</code> of length 6.

Format

The data "patlist_sim" is a trial generated by "SimPRMD". The model utilized
for generating trial is a 3-stage model with individualized dose modification.
The MTD = 4 and the MED = 1 since the dose-efficacy pattern when generating
the trial was set to be flat. The dose-toxicity trend and efficacy-cycle trend
are flat. There are in total 12 cohorts with 3 patients in each cohort. This
also serves as an example of the input data of function <code><a rd-options='' href='RunPRMD'>RunPRMD</a></code>.

patlist_sim: A list of patient information

Description

Usage

Arguments

Value

Format