tox.matrix

<p>This data set is a four-dimension array (Dose, Cycle, Toxicity Type, Toxicity Grade) specifying the probabilities of the occurrences of certain grades for certain types of toxicities.</p>

datasets

Implements our Bayesian phase I repeated measurement design that accounts for multidimensional toxicity endpoints from multiple treatment cycles. The package also provides a novel design to account for both multidimensional toxicity endpoints and early-stage efficacy endpoints in the phase I design. For both designs, functions are provided to recommend the next dosage selection based on the data collected in the available patient cohorts and to simulate trial characteristics given design parameters. Yin, Jun, et al. (2017) <doi:10.1002/sim.7134>.

Jun Yin

phase1RMD

tox.matrix: Probability matrix for toxicity

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