tox_dat

<p>This data set provides the toxicity data from 9 patients with multiple treatment cycles, matching with the efficacy data.</p>

datasets

Implements our Bayesian phase I repeated measurement design that accounts for multidimensional toxicity endpoints from multiple treatment cycles. The package also provides a novel design to account for both multidimensional toxicity endpoints and early-stage efficacy endpoints in the phase I design. For both designs, functions are provided to recommend the next dosage selection based on the data collected in the available patient cohorts and to simulate trial characteristics given design parameters. Yin, Jun, et al. (2017) <doi:10.1002/sim.7134>.

Jun Yin

phase1RMD

Repeated Measurement Design for Phase I Clinical Trial

tox_dat function

<p>A data frame containing 183 observations.</p>

tox_dat: Patient toxicity data

Description

Usage

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References