N <- 100
B <- 100
n <- 50
nclust <- 5
clusters <- rep(1:nclust,each=n/nclust)
beta0 <- c(1,2)
set.seed(13)
#generate phmm data set
Z <- cbind(Z1=sample(0:1,n,replace=TRUE),Z2=sample(0:1,n,replace=TRUE),Z3=sample(0:1,n,replace=TRUE))
b <- cbind(rep(rnorm(nclust),each=n/nclust),rep(rnorm(nclust),each=n/nclust))
Wb <- matrix(0,n,2)
for( j in 1:2) Wb[,j] <- Z[,j]*b[,j]
Wb <- apply(Wb,1,sum)
T <- -log(runif(n,0,1))*exp(-Z[,c('Z1','Z2')]%*%beta0-Wb)
C <- runif(n,0,1)
time <- ifelse(T<C,T,C)
event <- ifelse(T<=C,1,0)
mean(event)
phmmdata <- data.frame(Z)
phmmdata$cluster <- clusters
phmmdata$time <- time
phmmdata$event <- event
fit.phmm <- phmm(Surv(time, event)~Z1+Z2+cluster(cluster),
~-1+Z1+Z2, phmmdata, Gbs = 100, Gbsvar = 1000, VARSTART = 1,
NINIT = 10, MAXSTEP = 100, CONVERG=90)
# Same data can be fit with lmer,
# though the correlation structures are different.
poisphmmdata <- pseudoPoisPHMM(fit.phmm)
library(lme4)
fit.lmer <- lmer(m~-1+as.factor(time)+z1+z2+
(-1+w1+w2|cluster)+offset(log(N)),
poisphmmdata, family=poisson)
fixef(fit.lmer)[c("z1","z2")]
fit.phmm$coef
VarCorr(fit.lmer)$cluster
fit.phmm$Sigma
logLik(fit.lmer)
fit.phmm$loglik
traceHat(fit.phmm)
summary(fit.lmer)@AICtab
AIC(fit.phmm)
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