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pksensi (version 1.0.0)

Global Sensitivity Analysis in Pharmacokinetic Modeling

Description

Applying the global sensitivity analysis workflow to investigate the parameter uncertainty and sensitivity in pharmacokinetic (PK) models, especially the physiologically-based pharmacokinetic (PBPK) model with multivariate outputs. The package also provide some functions to check the sensitivity measures and its convergence of model parameters.

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Install

install.packages('pksensi')

Monthly Downloads

293

Version

1.0.0

License

GPL (>= 3)

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Maintainer

Nan-Hung Hsieh

Last Published

October 30th, 2018

Functions in pksensi (1.0.0)

pk_model

Example PK Model for Sensitivity Analysis
solve_mcsim

Solve PK Model Through MCSim
tell2

The Decoupling Simulations
pksim

Pharmacokinetic Simulation from Sampling Parameter
rfast99

Extended Fourier Amplitude Sensitivity Test with Random Phase Shift
solve_fun

Solve PK Model Through deSolve Package or Analytical Function
about-pksensi

About pksensi package
check

Check the Parameter Sensitivity
compile_model

Model Compiler
install_mcsim

Install MCSim