APAP

The APAP dataset contains a human experiment of pharmacokinetic data
for acetaminophen, and it's major metabolites.

datasets

Applying the global sensitivity analysis workflow to investigate the parameter uncertainty and sensitivity in pharmacokinetic (PK) models, especially the physiologically-based pharmacokinetic (PBPK) model with multivariate outputs. The package also provide some functions to check the sensitivity measures and its convergence of model parameters.

Nan-Hung Hsieh

pksensi

Global Sensitivity Analysis in Physiologically Based Kinetic
Modeling

Brad Reisfeld

Weihsueh A. Chiu

APAP function

A data frame containing the following columns:<ul>
<li>Wt: averaged weight of the study population (kg).</li>
<li>Dose: given oral dose of acetaminophen administered (mg/kg).</li>
<li>Time: time after drug administration (hr).</li>
<li>APAP: concentration of acetaminophen in the sample (mg/L).</li>
<li>AG: concentration of acetaminophen-glucuronide in the sample (mg/L).</li>
<li>AS: concentration of acetaminophen-sulfate in the sample (mg/L).</li>
<li>Study: Sourced reference.</li>
</ul>

APAP: Pharmacokinetics of Acetaminophen

Description

Usage

Arguments

Format

References