Three examples are included: Flip-flop pharmacokinetic model,
one-compartment toxicokinetic model from httk (Pearce et al. 2017),
and acetaminophen pharmacokinetic model (Zurlinden et al. 2016).
Usage
FFPK(params, time, dose = 1)
pbtk1cpt_model()
pbpk_apap_model()
Arguments
params
a parameter matrix containing the input sample.
time
the given time-points.
dose
a given dose.
Functions
pbtk1cpt_model: Download pbtk1cpt.model file.
pbpk_apap_model: Download pbpk_apap.model file.
References
R. Pearce, R. Setzer, C. Strope, N. Sipes and J. Wambaugh, 2017,
httk: R Package for High-Throughput Toxicokinetics,
Journal of Statistical Software, 79(4), 1-26.
T. J. Zurlinden and B. Reisfeld, 2016,
Physiologically based modeling of the pharmacokinetics of acetaminophen
and its major metabolites in humans using a Bayesian population approach,
European Journal of Drug Metabolism and Pharmacokinetics, 79(4), 1-26.
# NOT RUN {params <- c(F = 0.9, KA = 1.2, KE = 0.2, V = 1.5)
t <- seq(0, 12, 0.1)
C <-FFPK(params = params, time = t)
plot(t, C, type = "l", xlab = "time", ylab = "concentration")
# }