pksensi (version 1.1.3)

models: Example PK Model for Sensitivity Analysis

Description

Three examples are included: Flip-flop pharmacokinetic model, one-compartment toxicokinetic model from httk (Pearce et al. 2017), and acetaminophen pharmacokinetic model (Zurlinden et al. 2016).

Usage

FFPK(params, time, dose = 1)
pbtk1cpt_model()
pbpk_apap_model()

Arguments

params

a parameter matrix containing the input sample.

time

the given time-points.

dose

a given dose.

Functions

• pbtk1cpt_model: Download pbtk1cpt.model file.

• pbpk_apap_model: Download pbpk_apap.model file.

References

R. Pearce, R. Setzer, C. Strope, N. Sipes and J. Wambaugh, 2017, httk: R Package for High-Throughput Toxicokinetics, Journal of Statistical Software, 79(4), 1-26.

T. J. Zurlinden and B. Reisfeld, 2016, Physiologically based modeling of the pharmacokinetics of acetaminophen and its major metabolites in humans using a Bayesian population approach, European Journal of Drug Metabolism and Pharmacokinetics, 79(4), 1-26.

Examples

# NOT RUN {
params <- c(F = 0.9, KA = 1.2, KE = 0.2, V = 1.5)
t <- seq(0, 12, 0.1)
C <-FFPK(params = params, time = t)
plot(t, C, type = "l", xlab = "time", ylab = "concentration")

# }