models

FFPK

pbtk1cpt_model

pbpk_apap_model

The example PK model that were used in sensitivity testing.
Three examples are included: Flip-flop pharmacokinetic model,
one-compartment toxicokinetic model from httk (Pearce et al. 2017),
and acetaminophen pharmacokinetic model (Zurlinden et al. 2016).

Applying the global sensitivity analysis workflow to investigate
the parameter uncertainty and sensitivity in physiologically based
kinetic (PK) models, especially the physiologically based
pharmacokinetic/toxicokinetic model with multivariate outputs.
The package also provides some functions to check the convergence
and sensitivity of model parameters. The workflow was first mentioned
in Hsieh et al., (2018) <doi:10.3389/fphar.2018.00588>, then further
refined (Hsieh et al., 2020 <doi:10.1016/j.softx.2020.100609>).

Nan-Hung Hsieh

pksensi

Global Sensitivity Analysis in Physiologically Based Kinetic
Modeling

Brad Reisfeld

Weihsueh A. Chiu

models function

<dl><dt>params</dt>
<dd>a numeric vector to define the input parameter value.</dd>
<dt>time</dt>
<dd>a numeric vector to define the given time point(s).</dd>
<dt>dose</dt>
<dd>a numeric value to define the given dose in flip-flop model.</dd></dl>

Arguments

<ul>
<li><code>pbtk1cpt_model()</code>: Download pbtk1cpt.model file.</li>
<li><code>pbpk_apap_model()</code>: Download pbpk_apap.model file.</li>
</ul>

Functions

Example PK Model for Sensitivity Analysis — models

<dl>

<dt>params</dt>
<dd>a numeric vector to define the input parameter value.</dd>


<dt>time</dt>
<dd>a numeric vector to define the given time point(s).</dd>


<dt>dose</dt>
<dd>a numeric value to define the given dose in flip-flop model.</dd>

</dl>

models: Example PK Model for Sensitivity Analysis

Description

Usage

Arguments

Functions

References

Examples