tell2

Integrate the decoupling simulations (parameter sequences) and estimation results
to compute the sensitivity measures.

Applying the global sensitivity analysis workflow to investigate
the parameter uncertainty and sensitivity in physiologically based
kinetic (PK) models, especially the physiologically based
pharmacokinetic/toxicokinetic model with multivariate outputs.
The package also provides some functions to check the convergence
and sensitivity of model parameters. The workflow was first mentioned
in Hsieh et al., (2018) <doi:10.3389/fphar.2018.00588>, then further
refined (Hsieh et al., 2020 <doi:10.1016/j.softx.2020.100609>).

Nan-Hung Hsieh

pksensi

Global Sensitivity Analysis in Physiologically Based Kinetic
Modeling

Brad Reisfeld

Weihsueh A. Chiu

tell2 function

<dl><dt>x</dt>
<dd>a list of storing information in the defined sensitivity function.</dd>
<dt>y</dt>
<dd>a numeric array generated from the solutions of <code>solve_fun</code>
or <code>solve_mcsim</code> function.</dd></dl>

Arguments

The Decoupling Simulations — tell2

<dl>

<dt>x</dt>
<dd>a list of storing information in the defined sensitivity function.</dd>


<dt>y</dt>
<dd>a numeric array generated from the solutions of <code>solve_fun</code>
or <code>solve_mcsim</code> function.</dd>

</dl>

tell2: The Decoupling Simulations

Description

Usage

Arguments