make_weights

`make_weights()` Internal Function to make weights

Provides tools to compute unbiased pleiotropic heritability estimates of complex diseases from genome-wide association studies (GWAS) summary statistics. We estimate pleiotropic heritability from GWAS summary statistics by estimating the proportion of variance explained from an estimated genetic correlation matrix (Bulik-Sullivan et al. 2015 <doi:10.1038/ng.3406>) and employing a Monte-Carlo bias correction procedure to account for sampling noise in genetic correlation estimates.

Yujie Zhao

pleioh2g

Estimation of Pleiotropic Heritability from Genome-Wide
Association Studies (GWAS) Summary Statistics

make_weights function

<dl><dt>chi1</dt>
<dd>chi-square</dd>
<dt>L2</dt>
<dd>ld score</dd>
<dt>wLD</dt>
<dd>wld score</dd>
<dt>N</dt>
<dd>sample size</dd>
<dt>M.tot</dt>
<dd>Number of SNPs</dd></dl>

Arguments

Internal Function to make weights - refer to ldscr R package (https://github.com/mglev1n/ldscr) — make_weights

<dl>

<dt>chi1</dt>
<dd>chi-square</dd>


<dt>L2</dt>
<dd>ld score</dd>


<dt>wLD</dt>
<dd>wld score</dd>


<dt>N</dt>
<dd>sample size</dd>


<dt>M.tot</dt>
<dd>Number of SNPs</dd>

</dl>

make_weights: Internal Function to make weights - refer to ldscr R package (https://github.com/mglev1n/ldscr)

Description

Usage

Value

Arguments