merge_sumstats

`merge_sumstats()` Merging summary statistics with LD-score files

Provides tools to compute unbiased pleiotropic heritability estimates of complex diseases from genome-wide association studies (GWAS) summary statistics. We estimate pleiotropic heritability from GWAS summary statistics by estimating the proportion of variance explained from an estimated genetic correlation matrix (Bulik-Sullivan et al. 2015 <doi:10.1038/ng.3406>) and employing a Monte-Carlo bias correction procedure to account for sampling noise in genetic correlation estimates.

Yujie Zhao

pleioh2g

Estimation of Pleiotropic Heritability from Genome-Wide
Association Studies (GWAS) Summary Statistics

merge_sumstats function

<dl><dt>sumstats_df</dt>
<dd>dataframe of sumstat</dd>
<dt>w</dt>
<dd>wld score</dd>
<dt>x</dt>
<dd>ld score</dd>
<dt>chr_filter</dt>
<dd>(numeric vector) Chromosomes to include in analysis. Separating even/odd chromosomes may be useful for exploratory/confirmatory factor analysis.</dd></dl>

Arguments

Merging summary statistics with LD-score files - refer to ldscr R package (https://github.com/mglev1n/ldscr) — merge_sumstats

<dl>

<dt>sumstats_df</dt>
<dd>dataframe of sumstat</dd>


<dt>w</dt>
<dd>wld score</dd>


<dt>x</dt>
<dd>ld score</dd>


<dt>chr_filter</dt>
<dd>(numeric vector) Chromosomes to include in analysis. Separating even/odd chromosomes may be useful for exploratory/confirmatory factor analysis.</dd>

</dl>

merge_sumstats: Merging summary statistics with LD-score files - refer to ldscr R package (https://github.com/mglev1n/ldscr)

Description

Usage

Value

Arguments